Mammary osteogenic sarcoma

Aubrey, D. A.; Andrews, George Reid

doi:10.1002/bjs.1800580621

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…Two interesting cases have already been reported. First, Aubrey & Andrews (11) have reported a patient with mammary osteosarcoma who had a clinical course similar to that of our patient. A breast tumor excised from the left breast showed no malignancy but did include microfibroadenoma and extensive intraductal cystadenoma.…”

Section: Discussionsupporting

confidence: 68%

“…Table 1 summarizes cases of primary mammary osteosarcoma reported since 1970 (10–25): 5 of 8 patients had elevated serum levels of alkaline phosphatase, 8 of 16 had metastases to the lung, and 8 of 15 died.…”

Section: Discussionmentioning

confidence: 99%

“…The histogenesis remains controversial. Several theories have been proposed (6, 10, 11). An intimate association between osteosarcomas and fibroadenomas or phyllodes tumors has been documented.…”

Section: Discussionmentioning

confidence: 99%

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Osteosarcoma arising in the breast

Sando¹,

Oka

Moriya

et al. 2006

APMIS

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We report on a 49-year-old woman with osteosarcoma arising in the breast. She had undergone two consecutive excision biopsies for right breast tumors at ages 40 and 42 years. The tumors were diagnosed as a fibroadenoma and a benign phyllodes tumor, respectively. At age 46 years, she noticed a gradually enlarging mass in the same breast. After 3 years, at age 49 years, total mastectomy was performed. The tumor occupied the entire breast and measured 12x9x8.5 cm. The tumor cells were spindle-shaped and pleomorphic, with large, irregular nuclei and distinct nucleoli. Many tumor cells had characteristics of osteoblastic and chondroblastic elements producing osteoid, osseous, and cartilaginous intracellular substances. Pathologic mitoses and apoptotic cells were frequent. Neoplastic cells had infiltrated the skin. Blood and lymph vessel invasion was present. Tumor cells expressed vimentin, osteopontin, vascular endothelial growth factor, CD10, and alkaline phosphatase, but did not express keratin. Chemotherapy was not effective. The patient died of multiple pulmonary metastases 9 months after mastectomy.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

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Osteosarcoma arising in the breast

Sando¹,

Oka

Moriya

et al. 2006

APMIS

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“…In addi tion all 4 patients treated with postoperative radiation therapy died of progressive disease [27,30,33,34]. Six patients in cluding our own had received combination chemotherapy [15,28,29,32,36]. The median survival of these patients was 30 months, and 2 patients have been long-term disease-free survivors after treatment with high-dose methotrexate, bleomycin, cyclophosphamide, DTIC and adriamycin in one case and with cisplatin, adriamycin and ifosfamide in the other [36,37].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…It appears therefore impor tant to look at the role of adjuvant chemotherapy in the treat ment of primary osteosarcoma of the breast. Based on data in the literature at least 9 of 18 patients had developed metas tatic disease, predominantly pulmonary metastases [13,[27][28][29][30][31][33][34][35]. Among 12 patients treated with surgical resection alone 8 died of progressive tumours with a median survival of 12 months after diagnosis [13,27,28,30,31,[33][34][35].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Primary Osteogenic Sarcoma of the Breast: Report of a Case and a Short Review of the Literature

1995

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Background: Extraosseous osteosarcoma is a rare disease with approximately 150 cases reported in the literature. Primary osteogenic sarcoma of the breast is considered a particularly rare localisation. Approximately 20 cases of osteogenic sarcoma of the breast have been reported in the literature. The radiographic findings of the primary lesion are often misinterpreted as benign fibroadenomas the diagnosis of this rare disease is based on histological criteria. Osteogenic sarcomas of the breast have a high tendency towards local recurrences early haematogenous pread particularly pulmonary metastases. Case Report: Osteogenic sarcoma of the breast was diagnosed in a 48-year-old woman. Following mastectomy axillary lymph node dissection the patient developed liver thoracic wall metastases. She obtained a complete remission to COSS-86 chemotherapy but subsequently relapsed died from disseminated tumour despite repeated surgical attempts postoperative radiotherapy palliative chemotherapy 24 months after the primary diagnosis. Conclusions: Based on the currently available data of the cases reported radical resection of the primary tumour including axillary lymph node dissection is probably the appropriate surgical approach for primary osteogenic sarcoma of the breast. Since chemosensitivity of this malignancy has been observed adjuvant treatment according to the regimens employed for the treatment of osteogenic sarcoma of the bone (COSS treatment protocol) is recommended in order to improve the otherwise poor prognosis of patients with osteogenic sarcoma of the breast.

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General Concepts and Pathology of Tumors of Osseous Origin

Greenfield¹

1977

Bone Tumors

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Mammary osteogenic sarcoma

Abstract: SUMMARYA rare breast tumour, an osteogenic sarcoma, is described and the literature relative to osseous neoplasia in the breast is briefly reviewed.

Cited by 13 publications

References 4 publications

Osteosarcoma arising in the breast

Osteosarcoma arising in the breast

Primary Osteogenic Sarcoma of the Breast: Report of a Case and a Short Review of the Literature

General Concepts and Pathology of Tumors of Osseous Origin

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