Mammary phyllodes tumour: a 15-year multicentre clinical review

Co, Michael; Chen, Clement; Tsang, Julia Y. S.; Tse, Gary M.; Kwong, Ava

doi:10.1136/jclinpath-2017-204827

Cited by 38 publications

(31 citation statements)

References 19 publications

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“…The data available in literature on Phyllodes tumours include retrospective reviews and large, single-centre studies. [5][6][7][8][9] The following points summarize what these studies tell us about the management of Phyllodes tumours: • Prognosis is excellent for Phyllodes tumours following surgical excision, with no requirement for adjuvant therapy. 5,6 • As long as the microscopic surgical margins are free of disease, the extent of surgery does not correlate with disease-free survival or local recurrence.…”

Section: What Does the Literature Tell Us?mentioning

confidence: 99%

“…7,8 • Distant recurrences are more frequent in patients with malignant tumours. 5 • The upgrade rate of fibroepithelial lesions to Phyllodes tumours following a period of observation is low. 9 We performed a retrospective review at our single tertiary referral centre of all patients who had undergone surgical therapy for Phyllodes Phyllodes breast tumours are fairly uncommon, and they can be benign, borderline or malignant.…”

Section: What Does the Literature Tell Us?mentioning

confidence: 99%

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Phyllodes tumour of the breast and margins: How much is enough?

Ogunbiyi

Perry

Jakate

et al. 2019

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Section: What Does the Literature Tell Us?mentioning

confidence: 99%

Section: What Does the Literature Tell Us?mentioning

confidence: 99%

Phyllodes tumour of the breast and margins: How much is enough?

Ogunbiyi

Perry

Jakate

et al. 2019

cjs

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“…Chemotherapy, hormonal therapy and radiotherapy have no proven benefits in the treatment of PT in regards to its recurrence and metastasis [ 9 ]. In a study by Kario et al .…”

Section: Discussionmentioning

confidence: 99%

Recurrent giant phyllodes tumour in a 17-year-old female: a rare case report

Yahaya

2020

Oxford Medical Case Reports

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Phyllodes tumours (PTs) are rare fibroepithelial tumours of the breast with incidence accounting for <1% in the general population. Availability of reports on PTs with size of 31 cm or more in diameter in the literature are extremely rare. Herein, the case of a 17-year-old female patient with a giant recurrent right breast PT is reported. Histologically, the tumour showed proliferation of stromal tumour cells consisting of spindle cells with uniform nuclear chromatin, inconspicuous nucleoli, abundant eosinophilic cytoplasm and proliferation labelling index for Ki67 of <10%. PTs require meticulous surgical excision due to the fact that they have a high rate of recurrence and status of surgical margins must be included in the pathology report. This is because recurrent cases of PTs tend to grow faster than the primary ones with a high chance of transforming to malignancy.

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“…The duration of metastasis after surgery is 7 months to 6 years in literature [ 9 ], however our case developed it early in 3 months. Large tumor size and malignant phyllodes tumor are shown to be predictive of metastasis [ 12 ]. It thus explains the metastasis in our case.…”

Section: Discussionmentioning

confidence: 99%

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report

Khanal

Singh

Bhandari

et al. 2018

Annals of Medicine and Surgery

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BackgroundPhyllodes tumors are spectrum of tumors ranging from benign to malignant. Malignant spectrum pose a management challenge for clinicians due to high risks of recurrence and metastasis. Malignant phyllodes tumor with brain, lung and adrenal metastases at the same time is rare.Case presentationA 37 years-old unmarried female presented with an ulcerated huge lump in left breast with severe bleeding. Trucut biopsy showed necrosis with spindle cell proliferation with atypia for which she underwent modified radical mastectomy with final diagnosis of malignant phyllodes tumor. Three months after surgery, patient presented with headache, which on further evaluation showed masses in lung, right adrenal and brain.ConclusionWe presented a rare case of malignant phyllodes tumor with clinical, imaging and histological findings with metastases to multiple sites early in course and poor outcome of the patient despite margin negative resection.

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Mammary phyllodes tumour: a 15-year multicentre clinical review

Abstract: Local recurrence of PTs occurs irrespective of the tumour grade. Surgical margin is the only amendable factor to reduce the chance of recurrence.

Cited by 38 publications

References 19 publications

Phyllodes tumour of the breast and margins: How much is enough?

Phyllodes tumour of the breast and margins: How much is enough?

Recurrent giant phyllodes tumour in a 17-year-old female: a rare case report

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report

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