Mammary Tumor Recurrence in Bitches After Regional Mastectomy

Stratmann, N.; Failing, Klaus; Richter, Andreas; Wehrend, Axel

doi:10.1111/j.1532-950x.2007.00351.x

Cited by 107 publications

(113 citation statements)

References 10 publications

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“…Likewise, carcinoma in mixed tumor represented 47.5% of malignant neoplasms in this study, and 20.5% on the study by Filho et al (2010) [23]. Frequencies reported in this study for each histological type differ from international literature reports [2] [15] [16], probably due to a lack of histological standardization for canine mammary tumors [24].…”

Section: Discussioncontrasting

confidence: 53%

“…Although there are numerous studies about disease development and progression, some questions concerning the surgical treatment remain unanswered [2].…”

Section: Introductionmentioning

confidence: 99%

“…Aggressive surgical procedures for the treatment of localized lesions may reduce the risk of developing new lesions in a small number of dogs, especially in young intact bitches [5]. Stratmann et al (2008) [2] also indicated radical mastectomy as the best surgical option, regardless of the number and the size of lesions. Authors reported a greater probability of new tumor growth ipsilateral to the first surgery, although statistical significance was not assessed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors

Horta¹,

Lavalle²,

Cunha³

et al. 2014

ABCR

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The best surgical technique for the treatment of mammary tumors in female dogs has been exhaustively debated among the scientific community. Despite biological knowledge of these tumors, some authors have suggested aggressive procedures, without any clinical advantage. The aim of this study was to evaluate the influence of surgical procedure on the overall survival, disease-free interval and new lesion development interval in dogs with mammary tumors treated according to established prognostic factors. This prospective study included 143 intact female dogs that underwent surgery for mammary neoplasms and were followed up for about 738.5 days. Each animal represented a repetition. Each surgical technique represented a group: lumpectomy (P1), mammectomy (P2), regional mastectomy without cranial abdominal gland involvement (P3), regional mastectomy with cranial abdominal gland involvement (P4), and radical mastectomy (P5). Considering only the first surgical event, 84.6% of animals had more than one mammary tumor, and tumors were identified in two mammary chains in 52.5%. There was no difference in ipsilateral and contralateral tumor development when surgical techniques were compared. Only 33 dogs developed new lesions in remaining mammary tissue, without correlation with primary lesion. Surgical technique had no effect on the overall survival, diseasefree interval and new lesion development interval in patients on this study, which respected oncological surgery principles and established prognostic factors for mammary gland tumors in dogs.

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Section: Discussioncontrasting

confidence: 53%

“…Although there are numerous studies about disease development and progression, some questions concerning the surgical treatment remain unanswered [2].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors

Horta¹,

Lavalle²,

Cunha³

et al. 2014

ABCR

View full text Add to dashboard Cite

show abstract

“…However, it stays unsatisfactory due to the consistently high mortality after the surgical resection (Kurzman et al 1986, Bostedt et al 1995, Wey et al 1999, Stratmann et al 2008. The treatment of choice for these patients is adjuvant application of cytotoxic drugs.…”

Section: Discussionmentioning

confidence: 99%

Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line

Zhou¹,

Zhang²,

Pei³

et al. 2017

Polish Journal of Veterinary Sciences

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Canine mammary tumors are the most common neoplasms in intact female dogs. The surgery cannot always solve the problem, chemotherapy are recommend to these patients. However, chemotherapy could always fail because of multidrug resistance (MDR). Through stepwise increasing 5-Fluorouracil (5-FU) concentration in the culture medium, a 5-FU-resistant canine mammary tumor cell line CMT7364/5-FU was established to disclose the molecular mechanism of the drug resistance. Cell morphology, cell sensitivity to drugs, growth curves, expression of proteins, and chemo-sensitivity in vivo were compared between the parental cell line and resistant cell line. As compared it to its parental cell line (CMT7364), CMT7364/5-FU showed different morphology, cross-resistant to other chemo-drugs and a prolonged population doubling time (PDT). The drug efflux pump proteins (ABCB1 and ABCG2) in CMT7364/5-FU were up-regulated. In vivo, the similar result revealed that CMT7364/5-FU cell line was more resistant to 5-FU. In conclusion, a 5-FU-resistant canine mammary tumor cell line (CMT7364/5-FU) was successfully established, it can serve as a good model for researching the mechanism of MDR and screening effective agents to reverse drug resistance.

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“…Unilateral mastectomy is the treatment of choice for mammary tumours in bitches (Stratmann et al, 2008) and it consists of complete surgical removal of one mammary gland chain, adjacent tissues, and lymph nodes. This technique results in an extremely painful post-operative period (Lana et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Pre-emptive methadone or tramadol analgesia for mastectomy and ovariohysterectomy in bitches

Uscategui

Tiosso

Moro

et al. 2017

Rev Colomb Cienc Pecu

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Analgesia preventiva con tramadol o metadona para mastectomia y ovario histerectomía en perrasAnalgesia preventiva com tramadol ou metadona para mastectomia e ováriohisterectomia em cadelas Abstract Background: mastectomy and ovariohysterectomy (OVH) in bitches are critical surgeries and pain control can be challenging. Objective: to evaluate the efficacy of pre-emptive analgesia with methadone (MET) or tramadol (TRA) in postoperative pain intensity, cardiorespiratory effects, and anaesthetic/analgesic consumption in female dogs undergoing mastectomy and OVH. Methods: a prospective randomized blind clinical trial was used to evaluate 48 bitches of various breeds, aged 10 ± 3.7 years, weighing 16 ± 12 Kg, and with multiple mammary tumours. The animals were distributed in two groups: TRA group received 5 mg/Kg tramadol and MET group 0.5 mg/Kg methadone intramuscularly, 10 min prior to anaesthesia induction with propofol followed by maintenance with isoflurane. Heart (HR) and respiratory (RR) rates, mean arterial pressure (MAP), propofol induction dose (PID), oxyhemoglobin saturation (SpO 2 ), end-tidal isoflurane concentration (EtISO), and carbon dioxide pressure (EtCO 2 ) were measured during the intra-operative period. Post-operative pain was evaluated for 12 h and rated according to the Melbourne scale. Rescue analgesia (0.5 mg/Kg methadone, 2 mg/Kg lidocaine, or 0.01 mg/Kg/min ketamine IV) was given when necessary and post-operative analgesic consumption recorded. Statistical tests were used to compare treatments. Results: rescue analgesia requirements, pain score, PID and analgesic consumption were significantly lower (p<0.05) in MET group. The HR was higher in TRA group, while EtCO 2 and MAP were higher in MET group (p<0.05). Conclusion: methadone was more effective than tramadol in pre-emptive analgesia but not completely adequate on controlling pain in bitches subjected to

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Mammary Tumor Recurrence in Bitches After Regional Mastectomy

Abstract: This should be taken into account when deciding on the surgical management (radical or regional mastectomy) in dogs with single mammary tumors.

Cited by 107 publications

References 10 publications

Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors

Influence of Surgical Technique on Overall Survival, Disease Free Interval and New Lesion Development Interval in Dogs with Mammary Tumors

Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line

Pre-emptive methadone or tramadol analgesia for mastectomy and ovariohysterectomy in bitches

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