Mammary Tumours in Dogs and its Treatment Option- A Review

Fesseha, Haben

doi:10.26717/bjstr.2020.30.004980

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…The decisional process of the clinician should start with a complete evaluation of the patient, in order to assess its suitability for mastectomy and to decide the appropriate surgical technique and whether to include gonadectomy in its surgical plan. Patients presenting with mammary tumors should be carefully checked for evidence of metastatic disease 30 , starting with the evaluation of regional lymph nodes. These organs are difficult to assess when normal, and the easily palpable ones should be checked, possibly indicating regional metastasis 1,31 , to be confirmed through cytological examination.…”

Section: Discussionmentioning

confidence: 99%

“…Although in our study, we could not evaluate the effect of previous pregnancies or pseudo-pregnancies due to the lack of data, future research should investigate these as potential factors influencing the development of mammary tumours. Patients presenting with mammary tumours should be carefully checked for evidence of metastatic disease, 30 starting with the evaluation of regional lymph nodes. These organs are difficult to assess when normal, and the easily palpable ones should be checked, possibly indicating regional metastasis, 1,31 to be confirmed through cytological examination.…”

Section: Discussionmentioning

confidence: 99%

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A retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy

Banchi

Morello

Bertero³

et al. 2021

Vet Comparative Oncology

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The aim of the present study was to retrospectively assess whether spaying at the same time of mastectomy increased disease-free survival (DFS) in bitches with mammary tumors and to investigate the utility of clinical data when designing a surgical plan that includes gonadectomy. Data from 225 bitches were retrieved. Only 116 were surgically treated. Among these, 52 bitches underwent mastectomy and ovariectomy and 46 bitches underwent mastectomy alone. Survival analysis by Kaplan-Meier and in-between groups comparisons using Student's T, Chi-square, and one-way ANOVA tests were performed. Eighteen bitches were already spayed. DFS was longer for bitches that underwent ovariectomy and mastectomy compared to those that were left intact (P=0.00064) or were already spayed (P=0.0098). Spaying status affected the tumor size (spayed: 2.75 cm±2.72; intact: 1.76 cm±2.04; P=0.039), but not malignancy (P>0.05). Differences in age were detected between animals with benign and malignant tumors (9.1±2.8 and 10±2.3; P=0.004), with multiple and single tumors (10.18±2.6 and 9.3±2.8; P=0.007), and between purebred and mixed breed bitches (10.46 years ±1.78 and 9.27 years ±2.68; P = 0.005). Malignant tumors were larger than benign ones (2.17 years ±2.31 and 1.34 years ±1.82; P = 0.005) and size increased according to the degree of malignancy. DFS was shorter for animals presenting tumors >2 cm in size (P<0.006) and with tumors in the first pair of thoracic mammary glands (P=0.00009).Gonadectomy should be suggested to owners of intact bitches carrying mammary tumors and age, size of the tumor, and location should be carefully considered when performing surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy

Banchi

Morello

Bertero³

et al. 2021

Vet Comparative Oncology

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“…A genome-wide association study (GWAS) is a useful tool for understanding genetic and phenotypic variation. However, its usefulness is dependent on the level of linkage disequilibrium (LD) as only a limited number of markers can be genotyped ( 9 , 10 ). In one study, canine LD was found to be 20–50 times more extensive than that in humans, indicating that fewer SNPs are required for genotype analysis in dogs than in humans ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…There are limited studies of genetic mutations involved in the development of canine MGTs. In one study, one single-nucleotide polymorphism (SNP) in the BRCA1/2 genes, in which mutations are known to be associated with an 84% increased risk of breast cancer in human medicine, was confirmed to be significantly associated with canine MGTs ( 1 , 9 ). In another study, the significance of 10 genes associated with human breast cancer was analyzed in dogs with MGT ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study of mammary gland tumors in Maltese dogs

Kim,

Song,

Joo

et al. 2023

Front. Vet. Sci.

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BackgroundA genome-wide association study (GWAS) is a valuable tool for investigating genetic and phenotypic variation in many diseases.ObjectiveThe objective of this study was to identify variations in the genomes of Maltese dogs that are associated with the mammary gland tumor (MGT) phenotype and to assess the association between each biological condition and MGT phenotype in Maltese dogs.MethodsDNA was extracted from 22 tumor samples and 11 whole blood samples from dogs with MGTs. Genome-wide single-nucleotide polymorphism (SNP) genotyping was performed, and the top 20 SNPs associated with various conditions and genetic variations were mapped to their corresponding gene locations.ResultsThe genotyping process successfully identified 173,662 loci, with an overall genotype completion rate of 99.92%. Through the quality control analysis, 46,912 of these SNPs were excluded. Allelic tests were conducted to generate Manhattan plots, which showed several significant SNPs associated with MGT phenotype in intergenic region. The most prominent SNP, located within a region associated with transcription and linked to the malignancy grade of MGT, was identified on chromosome 5 (p = 0.00001) though there may be lack of statistical significance. Other SNPs were also found in several genes associated with oncogenesis, including TNFSF18, WDR3, ASIC5, STAR, and IL1RAP.ConclusionTo our knowledge, this is the first GWAS to analyze the genetic predisposition to MGT in Maltese dogs. Despite the limited number of cases, these analyzed data could provide the basis for further research on the genetic predisposition to MGTs in Maltese dogs.

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“…The tumor incidence rate increases rapidly in animals from approximately six years of age. The average age of dogs with mammary gland tumors is 10 to 11 years (Fesseha, 2020;Valdivia et al, 2021). Treatment of mammary gland tumors is through the surgical approach of mastectomy namely removal of mammary gland tumors.…”

Section: Introductionmentioning

confidence: 99%

Pyometra and mammary gland tumor in a Beagle dog at the Veterinary Teaching Hospital of Brawijaya University, Malang, Indonesia

Nofan Rickyawan,

Dian Vidiastuti,

Karlina Karlina

et al. 2023

Ovz

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A 12-year-old Beagle dog weighing 7.7 kg was brought to the Brawijaya University Veterinary Teaching Hospital in a state of dehydration, lethargy, and jaundice. On the 2nd day of hospitalization, the dog had mucopurulent discharge from the vagina. From the results of a complete blood count and ultrasonography (USG), the patient was diagnosed with pyometra and was treated with an ovariohysterectomy. After surgery the dogs was given cefotaxime 10 mg/kg bw, meloxicam 0.2 mg/kg bw, 0.9 ml vitamin K, and supportive therapy with Biodin® 0.5 mL and Modivitasan® 0.5 mL. Pyometra infection causes progesterone levels to rise, thereby triggering mammary gland tumor. On the 23rd day of hospitalization, a lump was found in the mammary gland. Fine needle aspiration (FNA) results showed the presence of Mott cells. The mammary gland tumor was treated with a single mastectomy. Mastectomy was performed when the dog was in stable condition, about a month after the ovariohysterectomy. Ovariohysterectomy and mastectomy were not performed simultaneously due to consideration of the patient's clinical condition, which made it impossible to get prolonged exposure to anesthesia. Post-mastectomy surgery the dogs were given cefixime 10 mg/kg bw, the analgesic meloxicam 0.2 mg/kg BW, and Biodin® 0.5 ml as supportive therapy. The postoperative wound healed well without complications. The patient recovered after one month of treatment.

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Mammary Tumours in Dogs and its Treatment Option- A Review

Cited by 6 publications

References 38 publications

A retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy

A retrospective study and survival analysis on bitches with mammary tumours spayed at the same time of mastectomy

Genome-wide association study of mammary gland tumors in Maltese dogs

Pyometra and mammary gland tumor in a Beagle dog at the Veterinary Teaching Hospital of Brawijaya University, Malang, Indonesia

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