Mammary-type myofibroblastoma of the thigh mimicking liposarcoma

Akhlaq, Natasha; Purgina, Bibianna; Werier, Joel; Jibri, Zaid

doi:10.1007/s00256-021-03891-9

Cited by 2 publications

(11 citation statements)

References 14 publications

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“…Clinically, extramammary myofibroblastoma tends to present as a slow‐growing painless mass or incidental finding 3,5 . It is most common in the fifth and sixth decades, having been reported in patients ranging from age 4 to 96 years, and has a slight male predominance 3,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Extramammary myofibroblastoma is commonly described as being variably positive for AR, ER, and PR. Though available data are limited to a few small case series and some case reports, cases of MF with positivity for a single, a combination of two, or all three steroid hormone receptors have been reported 5,9,13–18 . Conversely, 96% of SCLs are AR+, 19 and PR expression in SCL is rare 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Cellular angiofibroma is more easily distinguished from extramammary myofibroblastoma because of its prominent rounded, hyalinized vessels 3 . It is also typically CD34+ and desmin‐negative 5 . It tends to have wispy, rather than ropey or coarse, collagen 3,5 …”

Section: Discussionmentioning

confidence: 99%

“…It is also typically CD34+ and desmin‐negative 5 . It tends to have wispy, rather than ropey or coarse, collagen 3,5 …”

Section: Discussionmentioning

confidence: 99%

“…Extramammary myofibroblastoma, also known as “mammary‐type myofibroblastoma,” is a histopathologically and genetically identical lesion occurring outside the breast which was first reported some years later 2 ; it has since come to light that extramammary myofibroblastoma may be at least as common as its mammary counterpart 3 . It consists of fascicles of spindle cells with broad bundles or sheets of hyalinized collagen and varying amounts of adipose tissue 4,5 . It is classically positive for desmin and CD34 and belongs, along with spindle‐cell lipoma (SCL) and cellular angiofibroma, to the 13q14 deletion/RB1 loss family of tumors 4 .…”

Section: Introductionmentioning

confidence: 99%

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Extramammary myofibroblastoma of the oral cavity

et al. 2022

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Myofibroblastoma is a rare, benign mesenchymal tumor first described as a neoplasm of the breast. Extramammary myofibroblastoma is a histopathologically and genetically identical lesion occurring outside the breast. Herein is presented a case of extramammary myofibroblastoma arising in the oral cavity. A 59-year-old woman presented with a 1.5 cm nodule on the buccal surface of the lower lip. Wide local excision was performed. Histopathologic examination revealed haphazard fascicles of monomorphic spindle cells with hyalinized collagen bundles without fat. The spindled cells were diffusely positive for CD34, and focally for progesterone receptor. Desmin, smooth muscle actin, estrogen receptor, androgen receptor, S100, and STAT6 were negative. Rb1 expression was lost in tumor cells. Thus, the diagnosis of extramammary myofibroblastoma was made. Differential diagnoses include spindle-cell lipoma and angiofibroma. All three tumors are members of the 13q14 deletion/RB1 loss family. Indolent but locally aggressive (solitary fibrous tumor, desmoid fibromatosis) and frankly malignant (low-grade peripheral nerve sheath tumor, dermatofibrosarcoma protuberans) entities can be excluded by immunohistochemistry and careful microscopic examination. Extensive sampling extramammary myofibroblastoma is important to exclude the possibility of malignancy.Clinicians and pathologists alike should be aware of this entity and its potential to arise rarely in unusual locations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…It is also typically CD34+ and desmin‐negative 5 . It tends to have wispy, rather than ropey or coarse, collagen 3,5 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Extramammary myofibroblastoma of the oral cavity

et al. 2022

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Case report: A challenging case of mixed-variant myofibroblastoma with complex imaging and pathological diagnosis

Kawasaki,

Ichikawa,

Kanno

et al. 2024

Front. Oncol.

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Myofibroblastomas are benign mesenchymal tumors that frequently occur in the groin. They show variable morphology, and the differential histopathological diagnoses are broad, including lipomatous to myxoid tumors. In addition, both pathological and imaging findings may be complex, which makes diagnosis challenging. We herein present a case of a mixed-variant myofibroblastoma of the wrist in a 73-year-old woman. Considering the long clinical course of more than 20 years and the imaging findings, a benign myxoid tumor including a schwannoma was suspected; however, the histopathological findings from resected specimens suggested a diagnosis of myxofibrosarcoma. Additional histopathological findings led to a diagnosis of mixed-variant myofibroblastoma. The differential diagnosis of myofibroblastoma extends beyond imaging to pathological findings because of the number of possible variants. This case reinforces the notion that the gold standard treatment for soft tissue tumors is to perform surgery only after determining the correct diagnosis by biopsy.

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Mammary-type myofibroblastoma of the thigh mimicking liposarcoma

Cited by 2 publications

References 14 publications

Extramammary myofibroblastoma of the oral cavity

Extramammary myofibroblastoma of the oral cavity

Case report: A challenging case of mixed-variant myofibroblastoma with complex imaging and pathological diagnosis

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