Mammographic Breast Density, Body Mass Index, Menopausal Status, and Breast Cancer Risk

Mello‐Thoms, Claudia

doi:10.1001/jamanetworkopen.2021.39855

Cited by 6 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within these 8 patients, we did not observe any significant association between age and body mass index (BMI) with the cluster identity of their peri-tumoral samples. However, given that age and obesity are both major risk factors for breast cancer 19 , 20 and have been associated with breast density 21 , 22 , we sought to investigate in a larger cohort if they are also associated with the stromal gene signatures identified from our samples. We obtained RNA-seq data of normal breast samples from 145 healthy women without breast disease 23 and generated single-sample GSEA (ssGSEA) scores for each sample based on Cluster 1 and 2-upregulated genes found in Fig.…”

Section: Resultsmentioning

confidence: 99%

Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers

Lau,

Tan,

Tan

et al. 2023

npj Breast Cancer

View full text Add to dashboard Cite

Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study on the peri-tumoral stroma in the morphologically normal tissues surrounding the tumor is lacking. Here, we examine the heterogeneity in tumors and peri-tumoral stroma from 8 ER+/PR+/HER2− invasive breast carcinomas, through multi-region transcriptomic profiling by microarray. We describe the regional heterogeneity observed at the intrinsic molecular subtype, pathway enrichment, and cell type composition levels within each tumor and its peri-tumoral region, up to 7 cm from the tumor margins. Moreover, we identify a pro-inflammatory adipose-enriched peri-tumoral subtype which was significantly associated with poorer overall survival in breast cancer patients, in contrast to an adaptive immune cell- and myofibroblast-enriched subtype. These data together suggest that peri-tumoral heterogeneity may be an important determinant of the evolution and treatment of breast cancers.

show abstract

Section: Resultsmentioning

confidence: 99%

Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers

Lau,

Tan,

Tan

et al. 2023

npj Breast Cancer

View full text Add to dashboard Cite

show abstract

“…Furthermore, Hellmann et al reported a lower participation in organised screening in women who were underweight and in women who were morbidly obese [44]. Since BMI and age are inversely associated with breast density, the detection of suspicious masses on screening mammography should be easier in overweight and obese postmenopausal women [45,46].…”

Section: Discussionmentioning

confidence: 99%

Association of Body Mass Index with Clinicopathological Features and Survival in Patients with Primary Invasive Lobular Breast Cancer

Baelen

Nguyen

Hamy-Petit

et al. 2023

Preprint

View full text Add to dashboard Cite

“…Breast density is often a hereditary trait, which is measured by mammography representing the volume of fibroglandular (dense) tissue relative to fatty (non-dense) tissue. Breast density can also increase by using menopausal hormonal therapy and having a low body mass index [90][91][92]. TNBC can present with benign imaging features on mammography, ultrasound, or magnetic resonance imaging such as benign fibroadenomas, making imaging features of TNBC crucial [45].…”

Section: Breast Densitymentioning

confidence: 99%

Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy

Matou-Nasri,

Aldawood,

Alanazi

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Triple-negative breast cancer (TNBC) is usually the most malignant and aggressive mammary epithelial tumor characterized by the lack of expression for estrogen receptors and progesterone receptors, and the absence of epidermal growth factor receptor (HER)2 amplification. Corresponding to 15–20% of all breast cancers and well-known by its poor clinical outcome, this negative receptor expression deprives TNBC from targeted therapy and makes its management therapeutically challenging. Type 2 diabetes mellitus (T2DM) is the most common ageing metabolic disorder due to insulin deficiency or resistance resulting in hyperglycemia, hyperinsulinemia, and hyperlipidemia. Due to metabolic and hormonal imbalances, there are many interplays between both chronic disorders leading to increased risk of breast cancer, especially TNBC, diagnosed in T2DM patients. The purpose of this review is to provide up-to-date information related to epidemiology and clinicopathological features, risk factors, diagnosis, biomarkers, and current therapy/clinical trials for TNBC patients with T2DM compared to non-diabetic counterparts. Thus, in-depth investigation of the diabetic complications on TNBC onset, development, and progression and the discovery of biomarkers would improve TNBC management through early diagnosis, tailoring therapy for a better outcome of T2DM patients diagnosed with TNBC.

show abstract

Mammographic Breast Density, Body Mass Index, Menopausal Status, and Breast Cancer Risk

Cited by 6 publications

References 9 publications

Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers

Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers

Association of Body Mass Index with Clinicopathological Features and Survival in Patients with Primary Invasive Lobular Breast Cancer

Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy

Contact Info

Product

Resources

About