Mammographic features at primary breast cancer diagnosis in relation to recurrence-free survival

Lång, Kristina; Sturesdotter, Li; Bengtsson, Ylva; Larsson, Anna-Maria; Sartor, Hanna

doi:10.1016/j.breast.2024.103736

The Breast

2024

DOI: 10.1016/j.breast.2024.103736

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Mammographic features at primary breast cancer diagnosis in relation to recurrence-free survival

Kristina Lång,

Li Sturesdotter,

Ylva Bengtsson

et al.

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2024

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Breast cancer recurrence in relation to mode of detection: Implications on personalized surveillance

Sartor,

Hagberg,

Hemmingsson

et al. 2024

Preprint

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Purpose The effectiveness of current follow-up guidelines after breast cancer treatment is uncertain. Tailored surveillance based on patient age and tumor characteristics may be more adequate. This study aimed to analyze the frequency and risk factors for detecting ipsilateral locoregional recurrences (LR) and second primary breast cancers (SP) outside of scheduled surveillance in patients with recurrent breast cancer. Methods Patients with surgically treated early-stage breast cancer from the Malmö Diet and Cancer Study (MDCS), 1991–2014 (n = 1080), and the Västernorrland region, 2009–2018 (n = 1648), were included. Clinical and pathological information on the primary tumor and recurrences was retrieved from medical records. The mode of recurrence detection was defined as detection within (planned) or outside (symptomatic) of scheduled surveillance. Results The median follow-up was 6.5 years. Overall, 461 patients experienced a recurrence. The most common initial event was distant metastasis (47%), followed by locoregional recurrence (LR) (22%) and second primary (SP) (18%). Fifty-six percent of LR and 28% of SP were identified outside of scheduled surveillance. Logistic regression analysis revealed that younger age (under 50 years) (OR 2.57, 95% CI 1.04–6.88), lymph node-positive breast cancer (OR 2.20, 95% CI 1.03–4.87) and breast cancer of the HER2 positive subtype (OR 5.24, 95% CI 1.40–25.90) were correlated with higher odds of detecting a recurrence outside of planned surveillance. Conclusion Most recurrent events were detected outside of scheduled surveillance, particularly for locoregional recurrences. Risk-based surveillance, which takes into account patient and tumor characteristics, might be more suitable for specific patient subsets.

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Breast cancer recurrence in relation to mode of detection: Implications on personalized surveillance

Sartor,

Hagberg,

Hemmingsson

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Mammographic features at primary breast cancer diagnosis in relation to recurrence-free survival

Cited by 1 publication

References 40 publications

Breast cancer recurrence in relation to mode of detection: Implications on personalized surveillance

Breast cancer recurrence in relation to mode of detection: Implications on personalized surveillance

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