Mammographic features of triple receptor-negative primary breast cancers in young premenopausal women

Yang, Wei Tse; Dryden, Mark J.; Broglio, Kristine; Gilcrease, Michael Z.; Dawood, Shaheenah; Dempsey, Peter J.; Valero, Vicente; Hortobágyi, Gabriel N.; Atchley, Deann; Arun, Banu K.

doi:10.1007/s10549-007-9810-6

Cited by 144 publications

(139 citation statements)

References 37 publications

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“…The reason might be due to the diversity of race, menopausal status or weight in different regions. (Sachdev et al, 2010;Li et al, 2013;Somali et al, 2013) Similar to other studies (Crook et al, 1997;Noguchi et al, 1999;Claus et al, 2005;Yang et al, 2008), DCIS was rare among our TNBCs lacking mammographic calcifications. As we all know, calcifications were regarded as the specific pictures of DCIS.…”

Section: Discussionsupporting

confidence: 90%

“…TN DCIS develops rapidly in a brief period of time, making it difficult to be detected at a precancerous state. Yang et al (2008) suggested that biological differences exist among breast cancer subtypes and that TNBCs may have a distinct etiology. The results proved that TNBC was an aggressive cancer with a rapid progression to invasive cancer.…”

Section: Discussionmentioning

confidence: 99%

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Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Li¹,

Zhao²,

Dai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Li¹,

Zhao²,

Dai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…3,16 In our study, the index tumor was associated with DCIS in 83% of patients, contrary to the low incidence of associated DCIS in TNBC tumors described by others. 17 The clinical and pathologic features of the TNBCs observed in our study may reflect a slow growth rate or a less aggressive pattern of carcinogenesis, consisting of a stepwise pattern of progression from DCIS to invasive breast cancer. These Original Article data underscore the importance of screening in populations identified at risk for high prevalence of TNBC, because early detection and treatment results in an excellent prognosis.…”

Section: Discussionmentioning

confidence: 63%

Favorable prognosis in patients with T1a/T1bN0 triple‐negative breast cancers treated with multimodality therapy

Gupta

King

et al. 2012

Cancer

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BACKGROUND:The authors evaluated the clinical characteristics, natural history, and outcomes of patients who had 1 cm, lymph node-negative, triple-negative breast cancer (TNBC). METHODS: After excluding patients who had received neoadjuvant therapy, 1022 patients with TNBC who underwent definitive breast surgery during 1999 to 2006 were identified from an institutional database. In total, 194 who had lymph node-negative tumors that measured 1 cm comprised the study population. Clinical data were abstracted, and survival outcomes were analyzed. RESULTS: The median follow-up was 73 months (range, 5-143 months). The median age at diagnosis was 55.5 years (range, 27-84 years). Tumor (T) classification was microscopic (T1mic) in 16 patients (8.2%), T1a in 49 patients (25.3%), and T1b in 129 patients (66.5%). Most tumors were poorly differentiated (n ¼ 142; 73%), lacked lymphovascular invasion (n ¼ 170; 87.6%), and were detected by screening (n ¼ 134; 69%). In total, 129 patients (66.5%) underwent breast-conserving surgery, and 65 patients (33.5%) underwent mastectomy. One hundred thirteen patients (58%) received adjuvant chemotherapy, and 123 patients (63%) received whole-breast radiation. The patients who received chemotherapy had more adverse clinical and disease features (younger age, T1b tumor, poor tumor grade; all P < .05). Results from testing for the breast cancer (BRCA) susceptibility gene were available for 49 women: 19 women had BRCA1 mutations, 7 women had BRCA2 mutations, and 23 women had no mutations. For the entire group, the 5-year local recurrence-free survival rate was 95%, and the 5-year distant metastasis-free survival rate was 95%. There was no difference between patients with T1mic/T1a tumors and patients with T1b tumors in the distant recurrence rate (94.5% vs 95.5%, respectively; P ¼ .81) or in the receipt of chemotherapy (95.9% vs 94.5%, respectively; P ¼ .63). CONCLUSIONS: Excellent 5-year locoregional and distant control rates were achievable in patients with TNBC who had tumors 1.0 cm, 58% of whom received chemotherapy. These results identified a group of patients with TNBC who had favorable outcomes after early detection and multimodality treatment. Cancer 2012;118:4944-52.

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“…Identifying, evaluating, and monitoring process measures in screening is a focus of the National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) initiative, in which participating centers report structured data on the processes of cancer screening, diagnosis, and management. Increasingly, scientific evidence indicates that breast cancer is not a single disease [4]; tumors with different genetic "signatures" differ in prognosis [5], and they perhaps differ in likelihood of early detection through screening [6]. By identifying and evaluating process and outcome measures across the cancer screening continuum, PROSPR aims to provide generalizable evidence for a risk-based model of breast cancer screening.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of an Automated Information Extraction Tool for Imaging Data Elements to Populate a Breast Cancer Screening Registry

et al. 2015

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Breast cancer screening is central to early breast cancer detection. Identifying and monitoring process measures for screening is a focus of the National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) initiative, which requires participating centers to report structured data across the cancer screening continuum. We evaluate the accuracy of automated information extraction of imaging findings from radiology reports, which are available as unstructured text. We present prevalence estimates of imaging findings for breast imaging received by women who obtained care in a primary care network participating in PROSPR (n=139,953 radiology reports) and compared automatically extracted data elements to a "gold standard" based on manual review for a validation sample of 941 randomly selected radiology reports, including mammograms, digital breast tomosynthesis, ultrasound, and magnetic resonance imaging (MRI). The prevalence of imaging findings vary by data element and modality (e.g., suspicious calcification noted in 2.6 % of screening mammograms, 12.1 % of diagnostic mammograms, and 9.4 % of tomosynthesis exams). In the validation sample, the accuracy of identifying imaging findings, including suspicious calcifications, masses, and architectural distortion (on mammogram and tomosynthesis); masses, cysts, non-mass enhancement, and enhancing foci (on MRI); and masses and cysts (on ultrasound), range from 0.8 to1.0 for recall, precision, and Fmeasure. Information extraction tools can be used for accurate documentation of imaging findings as structured data elements from text reports for a variety of breast imaging modalities. These data can be used to populate screening registries to help elucidate more effective breast cancer screening processes.

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Mammographic features of triple receptor-negative primary breast cancers in young premenopausal women

Abstract: The mammographic features of TRN breast cancer suggest more rapid carcinogenesis leading directly to invasive cancer, that may require adjunct imaging tools for early diagnosis.

Cited by 144 publications

References 37 publications

Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Favorable prognosis in patients with T1a/T1bN0 triple‐negative breast cancers treated with multimodality therapy

Evaluation of an Automated Information Extraction Tool for Imaging Data Elements to Populate a Breast Cancer Screening Registry

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