Mammographic findings and occupational exposure to pesticides currently in use on Crete

Dolapsakis, George; Vlachonikolis, I G; Varveris, C.; Tsatsakis, Aristidis

doi:10.1016/s0959-8049(01)00159-9

Cited by 43 publications

(13 citation statements)

References 20 publications

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“…It is apparent that complete understanding of toxicity of carbosulfan is necessary to study human health hazards and to establish guidelines for setting no observable adverse effect level (NOAEL) it is emphasized that threshold level of the chemical below which no effect would be seen depends on the method of testing for immune response, animals species, endocrine and nutritional status of the host and type of antigen against which the responses are studied. It is clear from the present study that the immune system may be a sensitive target for carbosulfan for which the exact molecular target or mechanism of immunotoxicity are not known and indeed for many compounds there are probably multiple targets and mechanism of action 53 . The explanation for immunosuppressive effect of carbosulfan therefore, may be at many levels.…”

Section: Discussionmentioning

confidence: 89%

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

Dhouib¹,

Abdeladhim²,

Lasram³

et al. 2014

IOSRJESTFT

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Section: Discussionmentioning

confidence: 89%

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

Dhouib¹,

Abdeladhim²,

Lasram³

et al. 2014

IOSRJESTFT

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“…Greenhouse intense farming is among the most common agricultural practices in some rural and semi-urban municipalities (codes: 8; 9; 22). Studies has already shown the increased risk of lung cancer mortality and lower survival among individuals exposed to pesticides at work, especially among female greenhouse workers [39, 40]. Previous studies have documented the association of pesticides/greenhouse farming and the development of chronic disease [41].…”

Section: Discussionmentioning

confidence: 99%

Lung cancer and tobacco smoking in Crete, Greece: reflections from a population-based cancer registry from 1992 to 2013

Sifaki-Pistolla¹,

Lionis²,

Georgoulias³

et al. 2017

Tob. Induced Dis.

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BackgroundThe Cancer Registry of Crete is a regional population database that collects cancer morbidity/mortality data along with several risk factors. The current study assessed the geographical variation of lung cancer among ever and never smokers in Crete during the last 20 years.MethodLung cancer patient records (1992–2013) including information on medical history and smoking habits were obtained from the Cancer Registry of Crete. Age-Adjusted Incidence Rates (AAIR), prevalence of smoking among lung cancer patients and the Population-Attributable Fraction (PAF%) of tobacco smoking were estimated. Kaplan-Meier curves, grouped per smoking status were constructed, and spatio-temporal analyses were carried out to assess the geographical variations of lung cancer and smoking (a = 0.05).ResultsNew lung cancer cases in Crete accounted for 9% of all cancers (AAIRboth genders = 40.2/100,000/year, AAIRmales = 73.1/100,000/year, AAIRfemales = 11.8/100,000/year). Ever smokers presented significantly higher incidence compared to ex-smokers (p = 0.02) and never smokers (p < 0.001). The highest increase was observed in ever smokers (AAIR1992 = 19.2/100,000/year, AAIR2013 = 25.4/100,000/year, p = 0.03), while never smokers presented the lowest increase from 1992 to 2013 (AAIR1992 = 5.3/100,000/year, AAIR2013 = 6.8/100,000/year, p = 0.2). The PAF% of lung cancer mortality is 86% for both genders (males: 89%, females: 78%). AAIRs ranged from 25 to 50/100,000/year, while significant geographical differences were observed among the municipalities of Crete (p = 0.02). Smokers living in the south-east urban regions presented higher risk of dying from lung cancer (RR = 2.2; 95%CI = 1.3–3.5).ConclusionsThe constant increase of lung cancer rates among both genders, especially in females, outlines the need for targeted, geographically-oriented, life-style preventive measures. Design of population-based screening programs, tobacco awareness campaigns and smoking cessation programs in lung cancer hot spots could be guide by these findings.

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“…Women who reported they did not use exposure protection when applying pesticides had a higher risk when compared with women who said they did not apply pesticides (OR ¼ 2.0; 95% CI, 1.0-4.3), but the study may have been susceptible to recall bias. In a study of women who went for mammograms in Crete, 76 those who worked with organophosphate and organocarbamate pesticides in greenhouses were at significantly higher risk for a variety of nonmalignant breast conditions. Although these conditions are not known to be breast cancer precursors, studies, such as this one, that could identify relevant, environmentally sensitive breast changes would be an important contribution.…”

Section: Duell 2000mentioning

confidence: 99%

Environmental pollutants and breast cancer

Brody

Moysich

Humblet

et al. 2007

Cancer

311

207

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Mammographic findings and occupational exposure to pesticides currently in use on Crete

Cited by 43 publications

References 20 publications

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

Lung cancer and tobacco smoking in Crete, Greece: reflections from a population-based cancer registry from 1992 to 2013

Environmental pollutants and breast cancer

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