Mammographic lesions suggestive of radial scars: microscopic findings in 40 cases.

Frouge, C.; Tristant, H; Guinebretière, Jean Marc; Meunier, Martine; Contesso, G; Paola, Roberto Di; Bléry, M

doi:10.1148/radiology.195.3.7753984

Cited by 107 publications

(42 citation statements)

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“…To add to the diagnostic difficulties posed by radial scars, they cannot be distinguished from spiculate cancers on mammography. Frouge et al 8 assessed 40 cases (20 radial scars and 20 carcinomas) exhibiting at least three of the Tabar and Dean criteria. The authors were unable to differentiate between the mammographic appearances of the radial scars and the cancers.…”

Section: Discussionmentioning

confidence: 99%

A review of needle core biopsy diagnosed radial scars in the Welsh Breast Screening Programme

Osborn

Wilton

Stevens

et al. 2011

annals

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INTRODUCTION Radial scars are benign breast lesions; their appearance on mammography may, however, mimic carcinoma. Needle core biopsy is performed for pre-operative diagnosis and, currently in Wales, all lesions with benign biopsy results are surgically excised. We have reviewed all cases of needle core biopsy-diagnosed radial scars from the Welsh breast screening programme, Breast Test Wales (BTW), and investigated the outcome of radial scars based on histology from surgical excision in order to evaluate the appropriateness of the current management of these lesions in Wales. PATIENTS AND METHODS All needle core biopsy diagnosed radial scars were identified from the BTW screening database from the start of screening in 1989 until the end of 2007. RESULTS A total of 118 patients were diagnosed with radial scars on needle core biopsy; two patients had bilateral radial scars. Median patient age was 54 years (range, 49-68 years). Ninety-five lesions (79%) were thought to be pure radial scars on needle core biopsy; however, only 81 pure radial scars were identified on excision biopsy histology. Carcinoma was present in seven patients and ductal carcinoma in situ in nine patients at excision biopsy. In two patients, the cancers occurred in lesions reported as pure radial scars on needle core biopsy. Twenty-two lesions showed atypical ductal or lobular hyperplasia (ADH/ALH) or both on excision biopsy; 14 of these lesions were classed as pure radial scars by needle core biopsy. CONCLUSIONS All core biopsy diagnosed radial scars, presenting as screen detected abnormalities, should be excised due to their association with premalignant and malignant conditions.

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Section: Discussionmentioning

confidence: 99%

A review of needle core biopsy diagnosed radial scars in the Welsh Breast Screening Programme

Osborn

Wilton

Stevens

et al. 2011

annals

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“…12,[15][16][17][18][19] The literature presents a confused picture with regard to the association of carcinoma with radial scar, with the incidence of associated breast carcinoma varying from 0% to 43%. 19,20,22,24,25,29,[31][32][33][34][35] The reported differences in the association of breast carcinoma with radial scars are difficult to reconcile. Many studies are limited by small numbers, the retrospective nature of the analysis, and sometimes by a selection bias of patients likely to be at risk of malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…30 Some studies reviewing radial scars have reported a high rate of association with DCIS and invasive carcinoma (up to 43% in one series). 18,19,29,30,33,34 These series derived patients from selected sources, such as a surgical service of a cancer hospital and other tertiary referral centers, where patients are more likely to be at risk of breast carcinoma. They were mostly case series, and not population-based studies.…”

Section: Discussionmentioning

confidence: 99%

Fourteen‐gauge needle core biopsy of mammographically evident radial scars

Cawson¹,

Malara²,

Kavanagh³

et al. 2003

Cancer

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The effect of pH on the precipitation of soy protein between pH 4 and 6.8 was investigated. Precipitation between pH 5.7 and 6.8 gave a binary liquid‐liquid separation in which a protein‐rich secondary liquid phase containing between 20 – 30 wt % protein of 80 – 99% purity in glycinin formed as droplets of 1 – 10 μm. The droplets could be coalesced upon centrifugation to form a homogeneous bottom liquid layer. The high‐protein concentration phase was stable (did not precipitate or crystallize) for up to several months when stored at 4°C. Stable high‐protein liquid phases have not previously been reported. In the pH region for which liquid‐liquid separation occurred (pH 6.15 to 5.35), the droplet‐size distribution was controlled by nucleation and growth. No drop breakage, and little or no drop coalescence was observed. Mixer speed and geometry did not have a large effect on the size of the protein‐rich droplets in suspension. Nucleation occurred in two separate bursts at pH 6.15 and pH 5.85, followed by growth of the new nuclei as pH was decreased. Thus, the drop‐size distribution was monomodal between 6.15 and 5.85, and bimodal between pH 5.85 and 5.35. At pH 5.6 and below, protein precipitated as amorphous material which intertwined with and bound primary particles into aggregates. These agglomerates grew with decreasing pH, particularly below pH 5.35, as more protein precipitated with amorphous material acting as a binder. The addition of NaCl prevented the liquid‐liquid separation at higher pH. Instead solid precipitates of a different morphology were formed at low‐pH only. © 2007 American Institute of Chemical Engineers AIChE J 2007

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“…However, larger radial scars are being detected with increasing frequency in women who undergo mammographic screening. The morphologic similarity of radial scars to cancer [8][9][10][11][12] and the finding of carcinoma in some radial scars [13][14][15] have suggested that these lesions may represent an early phase in the development of certain types of breast cancer. Several studies have evaluated the frequency of radial scars in women with breast cancer, but with conflicting results.…”

Section: Discussionmentioning

confidence: 99%