Mammography and ultrasound features of triple-negative breast cancer

Kojima, Yasuyuki; Tsunoda, Hiroko

doi:10.1007/s12282-010-0223-8

Cited by 84 publications

(55 citation statements)

References 11 publications

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“…This study showed that approximately 80% of TNBC patients had a visible tumour mass on mammography, and the masses were less frequently associated with microcalcification. This finding is consistent with previous studies [20][21][22][23][24][25][26] that observed TNBC was most commonly presented as a mass (58.2-100%), and the mass was less frequently associated with microcalcifications (4.7-29%). Our data showed that the shape of TNBC lesions was more likely to be round/oval (58.1%), which is consistent with previous studies.…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, TNBC is likely to manifest benign morphological features. Moreover, this study revealed that on mammography TNBC was less frequently associated with calcifications (total calcification: 25.9%, only calcification: 5.6%), which was consistent with other studies [20][21][22][23][24][25][26] (total calcification: 11.7%-36%, only calcification: 0%-13.6%). Yang et al 20 indicated that the relative low levels of calcification in TNBC were consistent with the low incidence of ductal carcinoma in situ in TNBC.…”

Section: Discussionsupporting

confidence: 92%

“…[20][21][22]25 The broadly rounded shape of the masses can be explained by the rapid growth of these tumours that do not produce stromal reaction in breast cancer. 27 However, in contrast with this study and others, [20][21][22][23][24][25] Krizmanich-Conniff et al 26 reported that TNBC was mainly characterized by irregular masses (49%). Moreover, other studies 20,21,25,26 showed that the most common margins of tumour masses on mammography were indistinct (45-55%); however, in this study, the most common mass margins on mammography were circumscribed (37.2%), and less commonly mass margins were microlobulated (25.6%), which was consistent with the study reported by Dogan et al 22 Our results confirmed the findings of previous studies [20][21][22][23][24][25][26] that showed TNBC was less likely to have spiculated margins.…”

Section: Discussioncontrasting

confidence: 86%

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Mammographic and clinicopathological features of triple-negative breast cancer

Gao¹,

Zhang²,

Sd³

et al. 2014

BJR

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Breast cancer is the most common malignancy observed in females. Histologically, breast cancer is a heterogeneous disease with different subtypes and pathology, treatment options and prognosis. 1 Bryan et al 2 for the first time in 2006 explicitly presented the definition of triple-negative breast cancers (TNBCs) based on the expression of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Other studies using gene expression profiling were able to classify breast cancer into five subtypes. 3,4 To date, TNBC is used frequently as a standard procedure to classify breast cancer patients for clinical care. TNBC is similar to the basal-like subtype, which is characterized by negative ER, PR and HER2 expression, and is associated with aggressive histology, poor prognosis and unresponsiveness to the endocrine therapies. 5,6 Moreover, TNBC has been used as a surrogate marker for the basal-like breast cancer, and approximately 80-90% of TNBCs are basallike breast cancers.7 Younger females have a higher rate of basal or breast cancer susceptibility gene mutation-related TNBC, whereas older females have a higher proportion of apocrine, normal-like and rare subtypes of TNBC, including neuroendocrine TNBC.8 Because only fewer specific targeting therapies and molecular therapies (such as endocrine or target therapy) are available than for other subtypes of breast cancer, the standard treatment for TNBC includes surgery combined with adjuvant chemotherapy and radiotherapy, but clinical outcome is poor. 7,9 Thus, early detection of this subtype of breast cancer is vital to improve the survival of patients.Although TNBC has been studied extensively in clinical and pathological literature, there are few reports on the radiological characteristics of this subtype of breast cancer. To date, mammography is known to be a precise diagnostic technique with high sensitivity and specificity in the evaluation of breast lesions, and the current reference standard in breast cancer screening is mammography with the sensitivity to detect early-stage breast cancer. Therefore, this study evaluated the mammographic and clinicopathological

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 86%

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Mammographic and clinicopathological features of triple-negative breast cancer

Gao¹,

Zhang²,

Sd³

et al. 2014

BJR

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“…In our study, 67.7% of TN cancers were seen as round, oval, or lobulated masses, compared with 70% [10] to 75% [11] in previously reports. We found circumscribed margins in the TN lesions less often than was described in other studies [10.8% vs. 24% [4] to 43% [11]. In our study, circumscribed margins occurred in similar rates in TN and HR-positive/HER-2-negative tumors .…”

Section: Mammographysupporting

confidence: 55%

Triple-Negative Breast Cancers: Associations Between Imaging and Pathological Findings for Triple-Negative Tumors Compared With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-2-Negative Breast Cancers

Boisserie-Lacroix¹,

MacGrogan²,

Debled³

et al. 2013

The Oncologist

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Purpose. Triple-negative (TN) breast cancers have high malignancy potential and are often characterized by early systemic relapse. Early detection is vital, but there are few comprehensive imaging reports. Here we describe mammography, ultrasound, and magnetic resonance imaging (MRI) findings of TN breast cancers, investigate the specific features of this subtype, and compare the characteristics of TN breast cancers with those of hormone receptor (HR)-positive/human epidermal growth factor receptor (HER)-2-negative breast cancers. Materials and Methods. From July 2009 to June 2011, mammography and ultrasound findings of 210 patients with pathologically confirmed TN (n ϭ 105) and HR-positive/HER-2-negative breast cancers (n ϭ 105) were retrospectively reviewed from our institutional database. Ultrasound vascularity was notified in 88 cases and elasticity scores were notified in 49 cases overall. Thirty-five patients underwent MRI (22 TN and 13 HR-positive/HER-2-negative). Mammograms, ultrasound, and MRI were reviewed according to the Breast Imaging-Reporting and Data System (BI-RADS) lexicon and classification. Results. TN breast cancers were more likely to show round, oval, or lobulated masses with indistinct margins on mammography than HR-positive/HER-2-negative breast cancers. On ultrasound, TN tumors were more likely than HR-positive/ HER-2-negative breast cancers to show circumscribed or microlobulated margins and no posterior acoustic features or posterior enhancement-positive. On MRI, TN cancers exhibited suspicious aspects more often than HR-positive/HER-2-negative cancers, often with rim enhancement-positiveHER-2 (84.6% of masses were classified BI-RADS 5). Conclusion. This study is the first to describe findings on mammography, ultrasound, and MRI for TN breast cancers with a matched HR-positive/HER-2-negative control group. Several distinctive morphological features of these aggressive tumors are identified that can be used for earlier diagnosis and treatment, and ultimately to improve outcomes. The Oncologist 2013;18:802-811 Implications for Practice: Our results suggest that there are correlations between underlying phenotypes and distinctive imaging features for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative/human epidermal growth factor receptor (HER)-negative cancers and ER-positive/EP-positive/HER-negative cancers. The findings show that the triple negative (TN) phenotype has a few characteristic radiological findings: an oval or lobulated mass with circumscribed or microlobulated margins and

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“…Additionally, the presence of shadowing was strongly associated with low grade (about 92% were low grade in their study). Kojima et al (17) mentioned that triple-negative breast cancers were more likely to be lobulated in shape and having circumscribed margins and less likely to show posterior attenuating. Our results confirm the findings of these studies.…”

Section: Discussionmentioning

confidence: 99%