Mammography as a Screening Tool for Diabetes

Dale, Paul S.; Mascarenhas, C.; Richards, Michael; Mackie, Gavin C.

doi:10.1016/j.jss.2008.11.837

Cited by 13 publications

(7 citation statements)

References 10 publications

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“…Arterial calcification in the breast, representing calcium deposits in the media of small arteries and arterioles, has been related to advanced age. Mammogram studies have found that the prevalence of arterial calcification is significantly greater in diabetic women 17,18 . In patients with long standing diabetes, calcifications in the media of arterioles are more frequently detected 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Mammogram studies have found that the prevalence of arterial calcification is significantly greater in diabetic women. 17,18 In patients with long standing diabetes, calcifications in the media of arterioles are more frequently detected. 19 Our observation that vascular calcification/degenerative in the DM adjacent tissue raises a possible hypothesis of the pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Diabetic mastopathy, a clinicopathological correlation of 34 cases

Dorokhova¹,

Fineberg²,

Koenigsberg

et al. 2012

Pathology International

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Diabetic mastopathy (DM) is an unusual fibrous disease of the breast. We report 34 cases with clinicopathological correlation and follow-ups. Patients mean age was 57 years and 24 had histories of diabetes mellitus. The DM presented as a palpable breast mass in 85.3% of the cases clinically. Image findings were often as an irregular hypoechoic mass (44.4%) on ultrasound and negative or non-specific density (67.6%) on mammogram. Histologically, we found that the majority of DM occurred in the upper outer/central part of the breast (76%) and the size ranged from 0.5 to 3.7 cm. All cases showed lymphocytic lobulitis and vasculitis, keloidal fibrosis, lobular atrophy and varying degree of epithelioid fibroblasts. Examining the surrounding normal tissue of the excision specimens revealed that the margins of DM were often poorly circumscribed and irregularly demarcated from the sounding breast tissue. Vascular calcifications were identified in 10 of 24 excisional specimens, suggesting a hypothesis that vascular damage and scar/wounding healing process could contribute to the pathogenesis of DM. Twenty-one cases had repeated procedures for uncertain descriptive diagnosis. This is the largest study of diabetic mastopathy to date with clinical and imagining correlation. Recognition of this benign entity is important to better understanding the pathogenesis and to avoid unnecessary procedures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diabetic mastopathy, a clinicopathological correlation of 34 cases

Dorokhova¹,

Fineberg²,

Koenigsberg

et al. 2012

Pathology International

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“…Our results and the findings of Taşkın et al (8) indicate a significant association between BACs and diabetes in women ,59 years of age, but not in older women, while Cetin et al (5) showed a much stronger relationship between BACs and diabetes in older women. In contrast, Dale et al compared 819 women with no history of diabetes or CAD and 790 diabetic women based on BAC prevalence in age-stratified groups and showed that even though the prevalence of BAC increased with age in both groups, BACs occurred significantly more in the diabetes group irrespective of age (10). The age-adjusted OR of having diabetes with BACs compared to not having BACs was 4.5 in that study.…”

Section: Discussionmentioning

confidence: 73%

Risk factors associated with breast arterial calcifications

Ilıca¹,

Aydoğan²,

Güvenç³

et al. 2011

Acta Radiol

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“…This raised concern for a merely circumstantial association between BAC and DM, confounded by age. In contrast, Dale et al 51 studied 819 mammograms and found the incidence of BAC significantly higher in the DM group (36.45%, 288 of 790 women with DM; P < .001) than in the participants without DM (10%, 86 of 819 nondiabetic women), irrespective of age and concluded that women with BAC were at 4.5-fold greater risk of having DM, especially in the younger group aged 40 to 60 years. The authors suggested to screen for DM in BAC-positive women of that age-group.…”

Section: Diabetes Mellitus and Bacmentioning

confidence: 90%

Can Incidental Vascular Calcifications at Mammography be Used as a Screening Biomarker for Heart and Kidney Disease?

et al. 2018

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Mammography is a screening test with extensive international application and financial infrastructure promoting accessibility and affordability. Designed specifically to detect microcalcifications, mammography is powered to detect calcifications in vessel walls. Breast arterial calcifications (BAC) are one of the most common incidental findings documented by mammography. This review considers the literature regarding BAC in relation to cardiovascular disease (CVD) and its risk factors. The aim is to assess the possibility of using BAC as an early surrogate imaging biomarker of CVD.

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Mammography as a Screening Tool for Diabetes

Cited by 13 publications

References 10 publications

Diabetic mastopathy, a clinicopathological correlation of 34 cases

Diabetic mastopathy, a clinicopathological correlation of 34 cases

Risk factors associated with breast arterial calcifications

Can Incidental Vascular Calcifications at Mammography be Used as a Screening Biomarker for Heart and Kidney Disease?

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