2014
DOI: 10.1021/cr4002935
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Man-Made Cytotoxic Steroids: Exemplary Agents for Cancer Therapy

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Cited by 94 publications
(52 citation statements)
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“…8 Modification of some these natural products have yielded lots of better cytotoxic steroidal compounds, for example OSW-1 9 and other semi-synthetic cytotoxic steroids with platinum complex or alkylating agent hybrids. 10,11 Diosgenin is a C27 spiroacetal steroidal sapogenin abundantly available in Dioscorea species, fenugreek, and Costus speciosus, 12 which has been used as a healthy food, as well as the anti-hypercholesterolemia, antihypertriacyl glycerolemia, antidiabetes and antihyperglycemia ingredient in traditional Chinese medicine. 13 The anticancer effect of diosgenin has been also reported with the mechanism of transformation, induction of apoptosis, suppression of proliferation, and disruption of cell membrane integrity.…”
mentioning
confidence: 99%
“…8 Modification of some these natural products have yielded lots of better cytotoxic steroidal compounds, for example OSW-1 9 and other semi-synthetic cytotoxic steroids with platinum complex or alkylating agent hybrids. 10,11 Diosgenin is a C27 spiroacetal steroidal sapogenin abundantly available in Dioscorea species, fenugreek, and Costus speciosus, 12 which has been used as a healthy food, as well as the anti-hypercholesterolemia, antihypertriacyl glycerolemia, antidiabetes and antihyperglycemia ingredient in traditional Chinese medicine. 13 The anticancer effect of diosgenin has been also reported with the mechanism of transformation, induction of apoptosis, suppression of proliferation, and disruption of cell membrane integrity.…”
mentioning
confidence: 99%
“…В обзоре R. Bansal и соавт., охватывающем литературу до 2012 г., приведены многочисленные примеры противоопухолевых препаратов -конъюгатов ДНК-алкилирующих агентов со стеринами, стероидами ряда андростана, эстрана, прегнана, а также их производными, содержащими различные замести-тели и / или структурные модификации колец A, B, C и D. Структуры некоторых из перечисленных конъюгатов изображены на рис. 2 [27].…”
Section: конъюгаты стероидов с лекарственными препаратамиunclassified
“…The synthesis of steroidal oximes has been of significant relevance in recent years, reflected in some reports in the literature about the possible anticancer properties of this class of compounds (Bansal & Acharya, 2014;Cui et al, 2009). Research regarding the selective synthesis of oximes and polyoximes of naturally occurring steroids is thus active.…”
Section: Structure Descriptionmentioning
confidence: 99%