Man with epigastric pain and persistently elevated serum lipase

Abstract

Serum lipase and amylase are commonly requested in individuals presenting with abdominal pain for investigation of acute pancreatitis. Pancreatic hyperenzymaemia is not specific for acute pancreatitis, occurring in many other pancreatic and non-pancreatic conditions. Where persistent elevation of serum lipase and amylase occurs in the absence of a diagnosed cause or evidence of laboratory assay interference, ongoing radiological assessment for pancreatic disease is required for 24 months before a diagnosis of benign pancreatic hyperenzymaemia can be made. We report a case of a 71-year-old man with epigastric pain and elevated serum lipase levels. He was extensively investigated, but no pancreatic disease was detected. He is asymptomatic, but serum lipase levels remain elevated 18 months after his initial presentation.

Which Alarm Symptoms Are Associated With Abnormal Gastrointestinal Endoscopy Among Thai Children?

“…These findings confirmed that these parameters are vital surrogate markers to determine the organic diseases of the GI tract, such as persistent intestinal infection, intestinal inflammation, celiac disease, and IBD [ 15 23 ]. Levels of serum pancreatic enzymes, namely, amylase and lipase, were likely to be increased in non-pancreatic disorders or conditions such as intestinal inflammation, gut obstruction, duodenal ulceration, coeliac disease, peritonitis, acute cholecystitis, renal insufficiency, head injury, burns, shock, diabetic ketoacidosis, and a critical illness [ 24 25 ], which could be possible causes for increased pancreatic enzyme levels. Our study reported a significant rise in serum lipase levels among children with abnormal endoscopy due to various possible co-incidences.…”

Familial Gullo’s Syndrome: a clinical case report

“…Unlike the very extensive Italian cases, reports in other countries are limited. In literature, few cases are reported in Japan [4,11], Belgium [14], USA [17,33], India [34], Taiwan [35], Brazil [36], Austria [37], Poland [38], Ukraine [39], Australia [40], Spain [41,42], Venezuela [43], Morocco [44], and Germany [45].…”