Management and outcome of hepatic artery thrombosis with whole-liver transplantation using donors less than one year of age

Xu, Min; Dong, Chong; Sun, Changku; Wang, Kai; Zhang, Wei; Wu, Di; Qin, He; Han, Chao; Yang, Yang; Zhang, Fubo; Wang, Zhen; Zheng, Weiping; Gao, Wei

doi:10.1016/j.jpedsurg.2022.05.009

Cited by 4 publications

(9 citation statements)

References 52 publications

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“…The use of magnification loupe was reported in 12 studies (Table 1). [5,16,[18][19][20]22,23,25,26,28,29,31] Doppler ultrasound imaging was performed as part of standard clinical routine in all centers, with varying screening protocols and assessment criteria (Supplemental Table S4, http://links.lww.com/LVT/A493). The anticoagulation protocol used was reported in 16 studies, with heparin most frequently used (n = 6).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The primary indication for LT was reported in 180 of the 328 patients, with 95 patients having biliary atresia and 34 having a metabolic disease (unable to distinguish between cirrhotic and noncirrhotic metabolic disease). [8,15,17,19,20,22,23,26,29,31] Donor type was reported in 216 of the 328 patients, with 39.4% (85 of 216) of patients having undergone living donor LT. [5,8,16,17,19,20,22,23,[25][26][27][28]30] Missing data prevented us from analyzing the impact of primary indication, donor type, and the other potential risk factors for each treatment.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…Nishida et al [30] Retrospective cohort 114 19 June 1994 to September 2001 -9.4 (13) -Stringer et al [31] Retrospective cohort -40 January 1990 to December 1999 Applied a 7.3 (29) -Sieders et al [5] Case Xu et al [16] 19…”

Section: Hepatic Artery Thrombosismentioning

confidence: 99%

“…The anticoagulation protocol used was reported in 16 studies, with heparin most frequently used (n = 6). [16,17,[25][26][27][28] Most studies did not report detailed information regarding cytomegalovirus status, retransplantation versus primary transplantation, use of arterial conduits, arterial variants and/or reconstructions, and operation time of transplantation.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Treatment strategies for hepatic artery complications after pediatric liver transplantation: A systematic review

Li,

Bokkers,

Dierckx

et al. 2023

Liver Transplantation

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This study aimed to evaluate the effectiveness of different treatments for hepatic artery thrombosis (HAT) and hepatic artery stenosis (HAS) after pediatric liver transplantation. We systematically reviewed studies published since 2000 that investigated the management of HAT and/or HAS after pediatric liver transplantation. Studies with a minimum of 5 patients in one of the treatment methods were included. The primary outcomes were technical success rate and graft and patient survival. The secondary outcomes were hepatic artery patency, complications, and incidence of HAT and HAS. Of 3570 studies, we included 19 studies with 328 patients. The incidence was 6.2% for HAT and 4.1% for HAS. Patients with an early HAT treated with surgical revascularization had a median graft survival of 45.7% (interquartile range, 30.7%–60%) and a patient survival of 61.3% (interquartile range, 58.7%–66.9%) compared with the other treatments (conservative, endovascular revascularization, or retransplantation). As for HAS, endovascular and surgical revascularization groups had a patient survival of 85.7% and 100% (interquartile range, 85%–100%), respectively. Despite various treatment methods, HAT after pediatric liver transplantation remains a significant issue that has profound effects on the patient and graft survival. Current evidence is insufficient to determine the most effective treatment for preventing graft failure.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Patient Characteristicsmentioning

confidence: 99%

Section: Hepatic Artery Thrombosismentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Treatment strategies for hepatic artery complications after pediatric liver transplantation: A systematic review

Li,

Bokkers,

Dierckx

et al. 2023

Liver Transplantation

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“…A significant proportion of this is seen in patients with recurrent biliary tract infection or asymptomatic biliary leakage with liver dysfunction ( 113 ). Thrombosis after liver transplantation has a high incidence rate and poor prognosis in children undergoing liver transplantation because it is difficult to diagnose in the early stages ( 114 ). It is well-recognized that neutrophils and platelets act as first responders to injuries and infections ( 115 ).…”

Section: Nets and Arterial Thrombosismentioning

confidence: 99%

Neutrophil extracellular traps and complications of liver transplantation

et al. 2022

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Many end-stage liver disease etiologies are attributed to robust inflammatory cell recruitment. Neutrophils play an important role in inflammatory infiltration and neutrophil phagocytosis, oxidative burst, and degranulation. It has also been suggested that neutrophils may release neutrophil extracellular traps (NETs) to kill pathogens. It has been proven that neutrophil infiltration within the liver contributes to an inflammatory microenvironment and immune cell activation. Growing evidence implies that NETs are involved in the progression of numerous complications of liver transplantation, including ischemia-reperfusion injury, acute rejection, thrombosis, and hepatocellular carcinoma recurrence. NETs are discussed in this comprehensive review, focusing on their effects on liver transplantation complications. Furthermore, we discuss NETs as potential targets for liver transplantation therapy.

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Letter to Editor in response to: Management and outcome of hepatic artery thrombosis with whole-liver transplantation using donors less than one year of age

Yilmaz

Kutlutürk²,

Koç³

et al. 2023

Journal of Pediatric Surgery

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Management and outcome of hepatic artery thrombosis with whole-liver transplantation using donors less than one year of age

Cited by 4 publications

References 52 publications

Treatment strategies for hepatic artery complications after pediatric liver transplantation: A systematic review

Treatment strategies for hepatic artery complications after pediatric liver transplantation: A systematic review

Neutrophil extracellular traps and complications of liver transplantation

Letter to Editor in response to: Management and outcome of hepatic artery thrombosis with whole-liver transplantation using donors less than one year of age

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