Management and prognosis of primary tracheal cancer: A national analysis

Nouraei, Seyed Mahmoud; Middleton, Steve; Nouraei, S.A.R.; Virk, Jagdeep Singh; George, P. J. M.; Hayward, Martin; Sandhu, Guri

doi:10.1002/lary.24123

Cited by 53 publications

(41 citation statements)

References 26 publications

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“…In the cancer registries, however, incidence data for trachea, bronchus and lung are grouped all together. Since tracheal cancer is extremely rare, lung data were not excluded from this study despite this imperfect match. Myeloid leukemia incidence data were matched with whole‐genome information for acute myeloid leukemia and chronic myeloid leukemia.…”

Section: Methodsmentioning

confidence: 99%

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Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations

López‐Lázaro

2018

Genes Chromosomes & Cancer

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Recent evidence indicates that the risk of being diagnosed with cancer in a tissue is strongly correlated (0.80) with the number of stem cell divisions accumulated by the tissue. Since cell division can generate random mutations during DNA replication, this correlation has been used to propose that cancer is largely caused by the accumulation of unavoidable mutations in driver genes. However, no correlation between the number of gene mutations and cancer risk across tissues has been reported. Because many somatic mutations in cancers originate prior to tumor initiation and the number of cell divisions occurring during tumor growth is similar among tissues, I use whole genome sequencing information from 22 086 cancer samples and incidence data from the largest cancer registry in each continent to study the relationship between the number of gene mutations and the risk of cancer across 33 tissue types. Results show a weak positive correlation (mean = 0.14) between these 2 parameters in each of the 5 cancer registries. The correlation became stronger (mean = 0.50) when gender-related cancers were excluded. Results also show that 1003 samples from 29 cancer types have zero mutations in genes. These data suggest that cancer etiology can be better explained by the accumulation of stem cell divisions than by the accumulation of gene mutations. Possible mechanisms by which the accumulation of cell divisions in stem cells increases the risk of cancer are discussed.

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Section: Methodsmentioning

confidence: 99%

“…In the cancer registries, however, incidence data for trachea, bronchus and lung are grouped all together. Since tracheal cancer is extremely rare, 26…”

Section: Selection Of Tissuesmentioning

confidence: 99%

Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations

López‐Lázaro

2018

Genes Chromosomes & Cancer

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“…The management protocol includes surgery/radiotherapy/chemotherapy/combination therapy. Tracheal tumors are an uncommon group of tumors, accounting for less than 1 % of all malignant tumors [2], of which a small percentage are mesenchymal in origin. Less than 3% of synovial sarcoma (SS) arises in the head and neck region [3].…”

Section: Introductionmentioning

confidence: 99%

Primary tracheal synovial sarcoma: a rare clinical entity with diagnostic challenges

Kumar

Kaushal

Kanaklata

et al. 2020

J Egypt Natl Canc Inst

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Background: The incidence of primary tracheal tumors is very low. Tracheal synovial sarcoma (SS) is even an extremely rare entity. Diagnosis of tracheal SS can be achieved with chromosomal translocation studies along with immunohistochemistry. Margin-free resection is the gold standard treatment. Case presentation: We report a case of tracheal SS, which presented with stridor with a history of chronic cough and was diagnosed with a battery of clinical investigations and managed successfully with tracheal resection surgery. In histology, it may mimic Ewing's sarcoma. Immunohistochemically, SS stains positive for cytokeratin, epithelial membrane antigen, vimentin, and S100. Chromosomal translocation t(X;18) (p11;q11) is found in almost all SS. This genetic signature is the gold standard diagnostic modality for these tumors. Conclusion: Diagnosis of tracheal synovial sarcoma is challenging because of the rarity of the disease and common presenting symptoms to other tracheal pathology and is supplemented with chromosomal translocation study along with histopathology and immunohistochemistry. Tumor coring before definite surgical resection facilitates lung perfusion in obstructive tracheal pathology. A multidisciplinary team approach for diagnosis and management along with long-term follow-up are warranted.

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“…Surgically resectable disease is for up to 5 cm of affected trachea only, to minimize postoperative debility. Prognosis is usually better for surgically resectable disease that is followed by radiotherapy, with a high five-year survival rate of up to 50% [1].…”

Section: Introductionmentioning

confidence: 99%

Tracheolaryngeal Squamous Cell Carcinoma with Extensive Mucosal Spread Without Metastasis in a Female

Asmar

Shweihat

Adams

et al. 2020

Cureus

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Management and prognosis of primary tracheal cancer: A national analysis

Abstract: Tracheal cancer is under-recognized and under-treated. Early diagnosis, access to interventional bronchoscopy, and surgical treatment in specialist units may improve the survival of patients with this condition.

Cited by 53 publications

References 26 publications

Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations

Cancer etiology: Variation in cancer risk among tissues is poorly explained by the number of gene mutations

Primary tracheal synovial sarcoma: a rare clinical entity with diagnostic challenges

Tracheolaryngeal Squamous Cell Carcinoma with Extensive Mucosal Spread Without Metastasis in a Female

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