Management and prognosis of pure primary squamous cell carcinoma of the breast

Benoist, P; Mureau, A.; Joueidi, Yolaine; Arbion, Flavie; Vildé, A.; Body, G.; Michenet, Patrick; Lévèque, Jean; Ouldamer, Lobna

doi:10.1016/j.jogoh.2018.06.007

Cited by 14 publications

(23 citation statements)

References 32 publications

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“…Les 10 patientes de la série de Mychaluk et al [9] avaient un âge moyen de 60,8 ans et allant de 46 à 73 ans. Dans leur série publiée en 2018, Benoist et al [15] ont revu les données de 12 patientes traitées pour un carcinome épidermoïde mammaire pur. L'âge moyen des patientes était de 71,58 ans avec des extrêmes de 56 et 91 ans.…”

Section: Discussionunclassified

“…Mychaluk et al [9] ont rapporté que parmi les 10 patientes, trois patientes avaient un antécédent personnel de cancer du sein homo-ou controlatéral, dont l'histologie était un carcinome canalaire infiltrant (deux fois) et un carcinome médullaire pour la dernière, qui présentait aussi une mutation BRCA1. Dans la série de Benoist et al [15], la parité moyenne était de 3,3 (zéro à 13) et deux patientes (parmi 12) étaient nullipares. Toutes étaient ménopausées.…”

Section: Discussionunclassified

“…Chez les trois patientes de Tayeb et al [5], l'apparition d'un nodule du sein était le motif exclusif de consultation et la taille moyenne du nodule était de quatre cm. Benoist et al [15] rapportent que toutes les patientes avaient des nodules palpables cliniquement. Liu et al [8] ont rapporté que la taille moyenne des masses était de 4,5 cm et que des adénopathies axillaires étaient palpables dans 41,4% des cas.…”

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Profils épidémiologiques et diagnostiques des carcinomes épidermoïdes mammaires à l’Institut Joliot Curie de Dakar

Khairane¹,

Charfi²,

Ka³

et al. 2021

Af J Oncol

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INTRODUCTION: Breast cancer is the first cancer in women and clearly constitutes a real public health problem. Although adenocarcinoma remains by far the most common histologic type, there are other types that vary in frequency. A particular form which is the squamous cell carcinoma holds our attention. MATERIALS AND METHODS: The clinical records of patient consultants at the Joliot Curie Institute in Dakar between January 1, 2016 and June 30, 2020 were reviewed. We have retained the cases of pure or mixed breast squamous cell carcinomas. RESULTS: Our study focused on three observations received and treated at the Joliot Curie Institute in Dakar. These patients were 48, 50 and 48 years old respectively. They did not have any particular medical history. They were all postmenopausal. They had consulted following a self-palpation of a breast nodule. The biopsy had concluded in a mammary squamous cell carcinoma. Two of the three patients were metastatic. CONCLUSION: At the end of our study, we recommend a larger scale study including several centers. The therapeutic sequences must be better evaluated and compared to the most frequent form, which is infiltrating ductal adenocarcinoma.

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Section: Discussionunclassified

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Profils épidémiologiques et diagnostiques des carcinomes épidermoïdes mammaires à l’Institut Joliot Curie de Dakar

Khairane¹,

Charfi²,

Ka³

et al. 2021

Af J Oncol

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“…5 To date, the literature on primary SCC of the breast has yielded inconsistent results due to isolated case reports and small case series. [6][7][8][9][10][11] Many studies suggested that it was an aggressive disease that behaved like poorly differentiated breast adenocarcinoma, and its clinicopathologic features were similar to the "basal-like" subtype of triple-negative breast cancer (TNBC). [12][13][14] SCC of the breast was often noted to be refractory to treatment.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] SCC of the breast was often noted to be refractory to treatment. 8 Because of its relatively poor prognosis, optimal treatment needs to be explored. 1,2 However, due to its low incidence, the value of radiotherapy for these patients has not been well defined.…”

Section: Introductionmentioning

confidence: 99%

Postoperative radiotherapy improves overall survival in patients with primary squamous cell carcinoma of the breast

Wang

Zhang

Luo

et al. 2020

Asia-Pac J Clncl Oncology

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Background: Primary squamous cell carcinoma of the breast (PSCCB) is a rare clinical classification of breast tumors. Little is known about its clinicopathological features, prognosis and potential therapeutic strategies. The purpose of this study is to evaluate the effect of postoperative radiotherapy (PORT) on patients with squamous cell carcinoma (SCC) of the breast. Methods:We retrospectively analyzed patients diagnosed with PSCCB in our center. All pathological slides were reviewed by an experienced pathologist to confirm the diagnosis. Furthermore, we searched the public database for patients with SCC of the breast. Then, we analyzed the clinicopathological features, treatment methods and patient outcomes. Results:We identified 14 patients with primary SCC of the breast in our center. Additionally, 739 patients with SCC of the breast from the Surveillance, Epidemiology and End Results (SEER) database were diagnosed between 1975 and 2016. Only 453 patients who underwent surgery were included in this study. Patients from the SEER database had a more advanced tumor node metastasis (TNM) stage than patients from our center. The median overall survival (OS) of all patients was 104 months (95% confidence interval [CI], 87.2-120.8 months), and the 5-year OS was 60.8% (95% CI, 56.1%-65.5%). Most of the patients (58%) tested negative for hormonal receptor expression.Multivariate analysis showed that PORT was an independent prognostic factor for OS. Conclusion:The results of our study demonstrate that SCC of the breast presents aggressive behavior with unique clinical characteristics. PORT improved OS significantly in patients with SCC of the breast. Longer-term studies are needed to confirm our findings.

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Preoperative MRI of breast squamous cell carcinoma: diagnostic value of distinguishing between two subtypes

Chen

et al. 2022

Clinical Radiology

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Management and prognosis of pure primary squamous cell carcinoma of the breast

Cited by 14 publications

References 32 publications

Profils épidémiologiques et diagnostiques des carcinomes épidermoïdes mammaires à l’Institut Joliot Curie de Dakar

Profils épidémiologiques et diagnostiques des carcinomes épidermoïdes mammaires à l’Institut Joliot Curie de Dakar

Postoperative radiotherapy improves overall survival in patients with primary squamous cell carcinoma of the breast

Preoperative MRI of breast squamous cell carcinoma: diagnostic value of distinguishing between two subtypes

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