Management and retrospective analysis of primary and metastatic sacral tumors and infections: evaluation with 73 cases

Arıkan, Murat; Toğral, Güray; Hastürk, Aşkın Esen; Aktaş, Erdem; Güngör, Şafak

doi:10.5606/ehc.2014.28

Cited by 6 publications

(8 citation statements)

References 34 publications

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“…Sacral resection is a procedure with the potential to influence quality of life drastically [1,3,6,11,16,19]. In sarcoma surgery, removal of tumor mass without extensive excision is essential.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with sacral chondrosarcoma typically complain of low-back pain, radicular pain, weakness, bowel or bladder dysfunction, and paresthesia. Imaging features of various spinal tumors are often present similar characteristics [3]. Once the diagnosis has been determined, surgical therapy may be undertaken, but surgical treatment for sacral tumors can be quite challenging, with complications of neural compression, spinopelvic instability, and suboptimal oncological resection [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Patient-Specific Three-Dimensional Model for a Safe Surgical Pathway in Sacral Chondrosarcoma

Öztürk

Özer

Süer

et al. 2018

Indian J Surg Oncol

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Sacral tumors are amongst the most challenging procedures to treat because of the complex anatomy. This study determined whether patient-specific models change preoperative planning decisions made in preparation for en bloc resection of complex sacral mass surgical procedures. Imaging showed a big encapsulated mass at the S2-3 level involving the neural foramina and obscuring the nerve roots. High-resolution images were acquired and utilized to generate a patient-specific 3D tumor model. The visual and tactile inspection of 3D models allowed the best anatomical understanding, with faster and clearer comprehension of the surgical anatomy. The 3D sacral model was for observation of previously unapparent anatomical details; with this new technology, surgeon can observe their planned surgical intervention, explore the patient-specific anatomy and extension of the tumor, and sharpen their procedure choices. Moreover, multiple planes showed how far the angles on the plane would extend for osteotomy of the sacrum. Another result was identifying correct guides and safe venture landmarks. The study helped to establish safe osteotomy line wherever the nerve roots were retained and enabled osteotomy by preserving bilaterally the S1 and S2 nerve roots for wide excision of wide excision of primary sacral tumor to get adequate bowel and bladder functions. Finally, it helped to determine whether or not the remaining bone in the sacrum is sufficient for spinopelvic stability and needed fixation. It was decided spinopelvic fixation was not necessary for this case. Surgical intervention of sacral tumors varies depending on the tumor, its size, extension, and location. Surgery can have profound risks including unnecessary nerve root resection spinopelvic instability and suboptimal oncological resection. 3D models help to transfer complex anatomical information to clinicians and provide guidance in the preoperative planning stage, for intraoperative navigation and for surgical training purposes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Patient-Specific Three-Dimensional Model for a Safe Surgical Pathway in Sacral Chondrosarcoma

Öztürk

Özer

Süer

et al. 2018

Indian J Surg Oncol

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“…Lokal nüks %50'lik oran ile en sık kordoma ve kondrosarkom grubunda görülmüştür. 16 Ülkemizden bu çalışmadaki lokal nüks oranı yurtdışındaki çalışmalar ile benzer sıklıkta olup, bizim çalışmamızda lokal nüks oranı önceki çalışmalardan farklı olarak daha az sıklıkta tespit edilmiştir.…”

Section: Discussionunclassified

Evaluation of Benign/Malign Primary Sacrum Tumors and Surgical Site Infections

Öztürk¹,

Akyol²,

Süer³

et al. 2018

Turkiye Klinikleri J Med Sci

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Am ma aç ç: : Literatürde sakrum tümörü ve cerrahisi oldukça azdır. Sakrumun primer tümörleri metastatik tümörlere göre daha seyrek görülmektedir. Bu çalışmada benign/malign primer sakrum tümörü nedeni ile ameliyat edilmiş olguların özellikleri ve operasyon sonrası ortaya çıkan cerrahi alan enfeksiyonların değerlendirilmesi amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Hastanemiz Ortopedi kliniğinde 2012-2018 yılları arasında patolojik inceleme ile benign/malign primer sakrum tümörü tanısı alan ve cerrahi tedavi uygulanan olguların kayıtları retrospektif olarak incelenmiştir. Olguların demografik özellikleri, komorbid hastalıkları, cerrahi ve medikal tedavi modelleri, cerrahi alan enfeksiyon sıklığı, operasyon sonrası yara yeri özellikleri, olguların vital bulguları, enfeksiyon gelişme süresi, enfeksiyon etkeni olan mikroorganizmalar, reenfeksiyon etkenleri, gelişme sıklığı, süresi ve 5 yıllık sağkalımları açısından retrospektif olarak incelenmiştir. B Bu ul lg gu ul la ar r: : Toplam 9 olgu, [beş erkek, dört kadın, ortalama yaş 38 yıl (21-74)] dahil edilmiştir. Patolojik inceleme ile 9 olgunun 3'ü (%33,3) kordoma, 3'ü (%33,3) ewing sarkom, biri (%11,1) malign schwannom, biri (%11,1) dev hücreli tümör ve biri (%11,1) kondrosarkom tanısı almıştır. Malign tümör tanılı 8 olgunun (%88,9) 6'sına geniş rezeksiyon bir olguya (%11,1) benign tümör tanısı ile intralezyonel küretaj uygulanmıştır. Olguların 6'sında (%66,7) operasyon sonrası cerrahi alan enfeksiyonu gelişmiştir. Pre-op ve/veya post-op radyoterapi ve kemoterapi alan olguların 3'ünde (%75) enfeksiyon saptanırken, operasyonda implantasyon kullananılanların tamamında operasyon sonrası enfeksiyon ortaya çıkmıştır. Tüm olgularda 5 yıllık sağkalım %77,7, cerrahi alan enfeksiyonu gelişenlerde ise %83,3 bulunmuştur. S So on nu uç ç: : Sakrektomi gibi geniş rezeksiyon yapılan ve rektuma yakın komşuluğu olan operasyonlar sonrasında enfeksiyonlar sık karşılaşılan bir problemdir. Cerrahi alan enfeksiyonu tedavisinde cerrahi debritman ve etkene yönelik antibiyoterapinin birlikte uygulanması da ayrıca önem taşımaktadır. A An na ah ht ta ar r K Ke el li im me el le er r: : Sakrum tümörleri; cerrahi alan enfeksiyonu A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : In literature, sacrum tumors and its surgery are very few. Primary tumors of sacrum are less common than metastatic tumors. In this study, it was aimed to evaluate the characteristics and the surgical site infections after surgery of the cases operated with benign/malign primer sacrum tumor. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We retrospectively reviewed records of cases of operated with diagnosed by pathological examination benign/malign primer sacrum tumors in our clinic between the years of 2012 and 2018. The demographic characteristics of the cases, comorbid diseases, applied surgical treatment modalities, post-operative surgical site infection frequency, post operative features of wound site, vital findings of cases, duration of post-operative infection deve...

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“…While tens of thousands of patients may be living with a given rare cancer (Orphanet, 2016), the geographic dispersion of rare cancer patients often limits the number of cases seen at any one institution. As a result, knowledge of rare cancers is often based on single-patient case reports (Tomich et al, 2017; Simonetti et al, 2016; Panda et al, 2016; Afani et al, 2016) or single-institution retrospective analyses that describe small cohorts of patients seen over many decades (Arikan et al, 2014; Karatayli-Ozgursoy et al, 2016; Worhunsky et al, 2015). This evidence, which can be anecdotal, is in stark contrast to the multi-institutional cancer statistics studies routinely reported for common cancer types (National Cancer Institute, 2016b).…”

Section: Introductionmentioning

confidence: 99%

Emerging Opportunities for Target Discovery in Rare Cancers

Sharifnia

Hong

Painter

et al. 2017

Cell Chemical Biology

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Rare cancers pose unique challenges to research due to their low incidence. Barriers include a scarcity of tissue and experimental models to enable basic research and insufficient patient accrual for clinical studies. Consequently, an understanding of the genetic and cellular features of many rare cancer types and their associated vulnerabilities has been lacking. However, new opportunities are emerging to facilitate discovery of therapeutic targets in rare cancers. Online platforms are allowing patients with rare cancers to organize on an unprecedented scale, tumor genome sequencing is now routinely performed in research and clinical settings, and the efficiency of patient-derived model generation has improved. New CRISPR/Cas9 and small-molecule libraries permit cancer dependency discovery in a rapid and systematic fashion. In parallel, large-scale studies of common cancers now provide reference datasets to help interpret rare cancer profiling data. Together, these advances motivate consideration of new research frameworks to accelerate rare cancer target discovery.

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Management and retrospective analysis of primary and metastatic sacral tumors and infections: evaluation with 73 cases

Cited by 6 publications

References 34 publications

Patient-Specific Three-Dimensional Model for a Safe Surgical Pathway in Sacral Chondrosarcoma

Patient-Specific Three-Dimensional Model for a Safe Surgical Pathway in Sacral Chondrosarcoma

Evaluation of Benign/Malign Primary Sacrum Tumors and Surgical Site Infections

Emerging Opportunities for Target Discovery in Rare Cancers

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