Management and Risk Reduction of Rheumatoid Arthritis in Individuals with Obstructive Sleep Apnea: A Nationwide Population-Based Study in Taiwan

Chen, Wei Sheng; Chang, Yu‐Sheng; Chang, Chi-Ching; Chang, Deh Ming; Chen, Yi Hsuan; Tsai, Chang Youh; Chen, Jinhua

doi:10.5665/sleep.6174

Cited by 15 publications

(15 citation statements)

References 49 publications

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“…The association of sleep quality and rheumatoid arthritis has been assessed by other studies [ 10 , 11 , 41 – 57 ]. Low sleep quality has been associated with increased pain, decreased physical activity and higher mental or physical fatigue [ 41 , 43 , 45 , 46 , 48 , 49 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…Rheumatoid arthritis is a chronic systemic inflammation mainly targeting the joints [ 9 ]. Investigations have shown the association of rheumatoid arthritis with comorbidities and several dimensions of lifestyle such as poor sleep [ 10 , 11 ], high prevalence of depression/anxiety in patients with rheumatoid arthritis [ 12 ]. Studies have shown negative impacts of smoking [ 13 ] and fast foods [ 14 ] on rheumatoid arthritis disease activity.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown negative impacts of smoking [ 13 ] and fast foods [ 14 ] on rheumatoid arthritis disease activity. Specifically, important among the lifestyle factors has been sleep insufficiency which has been shown to be associated with the severity of symptoms and signs in patients with rheumatoid arthritis [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of lifestyle and disease characteristics with self-rated wellness/health score in patients with rheumatoid arthritis

et al. 2021

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Objective To study the relationship of self-rated wellness/health and lifestyle in patients with rheumatoid arthritis. Methods Self-rated wellness/health, demographics, smoking, mood, sleep, physical activity, diet, symptoms/signs, body mass index and laboratory findings in 142 patients with rheumatoid arthritis were collected in the current cross-sectional study. Multivariable generalized additive model (GAM) was employed to study the association of self-rated wellness/health score and lifestyle factors. Results Female/male ratio was 116/26 and the mean (SD) age of sample was 52 (13) years. Mean (SD) self-rated wellness/health score out of 10 was 7.2 (1.63). Mean (SD) number of tender joints and swollen joints were 4.42 (4.55) and 4.00 (4.26), respectively. The mean sleep score was 29.5 out of 70. Patients went to bed more than one hour earlier during the weekdays compared to weekends (22:45 vs. 23:52 PM, respectively, p < 0.0001). They also woke up more than one hour earlier during the weekdays compared to the weekends (6:08 vs. 7:20 AM, respectively, p < 0.0001). Their nap duration during weekdays was about half an hour shorter than the nap duration on weekends (19.75 vs. 48.02 minutes, respectively, p < 0.0001). The mean mood and diet scores were 18.5/35 and 22.5/42, respectively. By backward elimination in multivariable regression model (GAM), disease duration, mood, sleep quality, weekdays sleep characteristics (sleep duration, time to go to bed, wake-up time, time to fall asleep and nap duration), and sleep duration on weekends remained in the final model (R2 = 0.225, p = 0.01). Sleep quality, nap duration on weekdays, night sleep duration on weekends and mood status were the significant variables associated with self-rated wellness/health score. Conclusion In patients with rheumatoid arthritis, the low self-rated wellness/health score was associated with the low sleep quality, long sleep duration on weekends, and long nap duration on weekdays.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of lifestyle and disease characteristics with self-rated wellness/health score in patients with rheumatoid arthritis

et al. 2021

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“…It appears that sleep-disordered breathing renders people more susceptible to immune-mediated disorders. OSA patients are at greater risk of diseases, such as psoriasis (prevalence 8.7%, compared to 2% in the general population), RA (adjusted hazard ratio (aHR) 1.33), SS-aHR 3.45), and BD-aHR 5.33 [ 81 , 103 , 104 ]. The interaction between the two, as in many such cases, might be bidirectional—the influence of immune-mediated diseases on the OSA development has already been discussed above.…”

Section: Sleep Disturbances In Immune Diseasesmentioning

confidence: 99%

“…According to one study, treatment with continuous positive airway pressure (CPAP) decreases HR to 0.22 for RA and 0.51 for other autoimmune diseases, which were not specified by the authors [ 103 ].…”

Section: Sleep Disturbances In Immune Diseasesmentioning

confidence: 99%

Sleep Problems in Chronic Inflammatory Diseases: Prevalence, Treatment, and New Perspectives: A Narrative Review

Ditmer

Gabryelska

Turkiewicz

et al. 2021

JCM

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Epidemiological studies have shown that individuals with sleep problems are at a greater risk of developing immune and chronic inflammatory diseases. As sleep disorders and low sleep quality in the general population are frequent ailments, it seems important to recognize them as serious public health problems. The exact relation between immunity and sleep remains elusive; however, it might be suspected that it is shaped by others stress and alterations of the circadian rhythm (commonly caused by for example shift work). As studies show, drugs used in the therapy of chronic inflammatory diseases, such as steroids or monoclonal antibodies, also influence sleep in more complex ways than those resulting from attenuation of the disease symptoms. Interestingly, the relation between sleep and immunity appears to be bidirectional; that is, sleep may influence the course of immune diseases, such as inflammatory bowel disease. Thus, proper diagnosis and treatment of sleep disorders are vital to the patient’s immune status and, in effect, health. This review examines the epidemiology of sleep disorders and immune diseases, the associations between them, and their current treatment and novel perspectives in therapy.

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Dangerous Liaisons: Obstructive Sleep Apnea, Dysbiosis, and Chronic Inflammation

Sánchez-Ramón,

Guzmán-Fulgencio

2023

Obstructive Sleep Apnea

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Management and Risk Reduction of Rheumatoid Arthritis in Individuals with Obstructive Sleep Apnea: A Nationwide Population-Based Study in Taiwan

Cited by 15 publications

References 49 publications

Association of lifestyle and disease characteristics with self-rated wellness/health score in patients with rheumatoid arthritis

Association of lifestyle and disease characteristics with self-rated wellness/health score in patients with rheumatoid arthritis

Sleep Problems in Chronic Inflammatory Diseases: Prevalence, Treatment, and New Perspectives: A Narrative Review

Dangerous Liaisons: Obstructive Sleep Apnea, Dysbiosis, and Chronic Inflammation

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