Management and Treatment of Patients With Major Depressive Disorder and Chronic Diseases: A Multidisciplinary Approach

Almeida, Susana; Zizzi, Francesca; Cattaneo, A.; Comandini, Alessandro; Dato, Giorgio Di; Lubrano, Ennio; Pellicano, Clelia; Spallone, Vincenza; Tongiani, Serena; Torta, Riccardo

doi:10.3389/fpsyg.2020.542444

Cited by 21 publications

(15 citation statements)

References 72 publications

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“…Likewise, the systematic review carried out by Almeida et al on depression and chronic diseases contains a section in which it analyzes depression in patients with PD. In its analyses it estimates that the prevalence of depression in these patients varies according to the studies, although it is estimated that between 50 and 70% of patients with PD are affected by depression [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…The general prevalence of depression in Parkinson’s patients is between 30 and 35% [ 5 ]. Although there are differences according to authors, Almeida et al, consider prevalence of depression to be between 50 and 70% in patients with PD [ 9 ]. A study with a large sample showed that prevalence was higher in women than in men [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Depression Symptoms in Patients with Parkinson’s Disease: A Novel Case-Control Investigation

Jiménez-Cebrián

Becerro-de-Bengoa-Vallejo

Iglesias

et al. 2021

IJERPH

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Parkinson’s disease is a common neurodegenerative disease and it is known to cause motor disturbances associated with musculoskeletal problems of the locomotor apparatus, and non-motor symptoms, that are believed to have a harmful effect on health, social functioning and mobility. The aim of this study was to evaluate depression in patients with Parkinson’s Disease (PD) compared to subjects who do not have it. The sample consisted of 124 participants (mean age 69.18 ± 9.12). Patients with PD were recruited from a center of excellence for Parkinson’s disease (cases n = 62) and healthy subjects without PD from their relatives and caregivers (control n = 62). The Spanish version of Beck’s Depression Inventory (BDI) scores and categories were collected. A clear statistically significant difference (p < 0.05) was evident in the BDI scores between both groups. Parkinson’s patients presented worse results on the BDI = 15.48 ± 7.24 points compared to healthy subjects with BDI = 7.03 ± 6.99 points. Regarding BDI categories, there were statistically significant differences (p < 0.001) for the greater BDI categories in the Parkinson’s group compared with healthy subjects. The depression represents an important potential risk for increased symptoms and negative impact among patients with PD compared with healthy subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Depression Symptoms in Patients with Parkinson’s Disease: A Novel Case-Control Investigation

Jiménez-Cebrián

Becerro-de-Bengoa-Vallejo

Iglesias

et al. 2021

IJERPH

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“…Prevalence of MDD in RA patients vary from 13% to 42%, two to four times higher than the prevalence in the general population [ 5 ]. Complications of depression reduce the treatment response of RA patients and increase the patients’ mortality [ 6 ]. Although the precise mechanisms underlying the high occurrence of depression in RA patients are unknown, abnormalities in gut microbiota composition may play a crucial role in link between RA and depression [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation

Zhang

Tang

et al. 2022

Transl Psychiatry

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Depression is common in patients with rheumatoid arthritis (RA); however, the precise mechanisms underlying a link between depression and RA remain unclear. Accumulating evidence suggests the role of gut–microbiota–brain axis in depression. In this study, we investigated whether collagen-induced arthritis (CIA) mice produce depression-like behaviors and abnormal composition of gut microbiota. Furthermore, we investigated whether fecal microbiota transplantation (FMT) from RA patients causes depression-like phenotypes in antibiotic cocktail (ABX)-treated mice. CIA mice displayed depression-like behaviors, increased blood levels of pro-inflammatory cytokine interleukin-6 (IL-6), decreased expression of synaptic proteins in the prefrontal cortex (PFC), and abnormal composition of gut microbiota. Furthermore, FMT from RA patients caused depression-like phenotypes, alterations of gut microbiota composition, increased levels of IL-6 and tumor necrosis factor-α (TNF-α), and downregulation of synaptic proteins in the PFC compared to FMT from healthy controls. There were correlations between relative abundance of microbiota and plasma cytokines, expression of synaptic proteins in the PFC or depression-like behaviors. Interestingly, FMT from RA patients induced T cells differentiation in Peyer’s patches and spleen. Reduced percentage of Treg cells with an increase of Th1/Th2 index was observed in the mice after FMT from RA patients. These findings suggest that CIA mice exhibit depression-like behaviors, systemic inflammation, and abnormal composition of gut microbiota, and that FMT from RA patients produces depression-like behaviors in ABX-treated mice via T cells differentiation. Therefore, abnormalities in gut microbiota in RA patients may contribute to depression via gut–microbiota–brain axis.

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“…Among factors associated with a lowering of the H-QoL, an important role has been recognized in several chronic diseases at the co-occurrence of Major Depressive Disorders [ 25 - 29 ]. Although some research has sought to elucidate the relationship between Major Depressive Disorders, H-QoL and cancer [ 18 , 30 , 31 ], this relationship has so far been little studied.…”

Section: Introductionmentioning

confidence: 99%

The Quality of Life of People with Solid Cancer is Less Worse than Other Diseases with better Prognosis, Except in the Presence of Depression

González¹,

Angermeyer²,

Deiana³

et al. 2021

CPEMH

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Background: Suffering from Solid Cancer (SC) may adversely impact the Health-related Quality of Life (H-QoL). The aims of this study are to measure the H-QoL in a sample of people suffering from SC and to clarify the role of the co-occurrence of depressive episodes. Results were compared with a healthy control group and with groups of other disorders. Methods: In 151 patients with SC (mean±sd age 63.1±11.5; female 54.3%), H-QoL was assessed by SF-12, depressive episodes were identified by PHQ-9. The attributable burden of SC in impairing H-QoL was calculated as the difference between SF-12 score of a community sex and age ¼ matched healthy control group and that of the study sample. The attributable burden of SC was compared with other chronic diseases using specific diagnostic groups drawn from case-control studies that used the same database for selecting control samples. Results: H-QoL in people with SC was significantly worse than in the healthy control group (p<0.0001). The attributable burden in worsening the H-QoL due to SC was similar to those of severe chronic diseases, but lower than Multiple Sclerosis (p<0.0001) or Fibromyalgia (p<0.00001). Having a depressive episode was a strong determinant of decreasing H-QoL, regardless of the severity of cancer. Conclusion: The findings confirm a strong impact of SC but showed that H-QoL in SC was higher than in chronic diseases with better “quoad vitam” outcome. Since depression was a strong determinant, its prevention, early detection and therapy are the main objectives that must be reached in cancer patients.

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Management and Treatment of Patients With Major Depressive Disorder and Chronic Diseases: A Multidisciplinary Approach

Cited by 21 publications

References 72 publications

The Impact of Depression Symptoms in Patients with Parkinson’s Disease: A Novel Case-Control Investigation

The Impact of Depression Symptoms in Patients with Parkinson’s Disease: A Novel Case-Control Investigation

Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation

The Quality of Life of People with Solid Cancer is Less Worse than Other Diseases with better Prognosis, Except in the Presence of Depression

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