The article is devoted to the development of institutional and organizational leadership in the leading scientific and technical sectors and fundamental research. The paper presents the characteristics of the categories “organizational leadership” and “institutional leadership”, the features of effective leadership. Methodological tools of the study: analysis of statistical sources of information. As the study showed, the formation and development of leading positions are influenced by a number of factors. Their analysis is carried out, tendencies of development of leadership in the leading scientific and technical sectors and fundamental researches are revealed. It is concluded that an important task is the choice of the country’s development in the field of science and technology. The author considers the ways in which it is possible to develop institutional and organizational leadership in the leading scientific and technical sectors and fundamental research.