Management der saisonalen Influenza 2017/2018: Erfahrungen an einem deutschen Universitätsklinikum

Abstract

Die saisonale Influenza ist eine akute, impfpräventable respiratorische Erkrankung, die durch das Influenzavirus (RNA, Orthomyxoviridae) verursacht wird [1]. Die Grippewelle der Saison 2017/2018 war die schwerste seit dem Jahr 2001 [2]. Etwa 65,0 % der nachgewiesenen Influenzainfektionen waren vom Influenza Typ B und gehörten fast ausschließlich der Yamagata-Linie an [2]. Die B-Komponente des während der Influenzasaison überwiegend genutzten, trivalenten Influenzaimpfstoffes basierte auf der Victoria-Linie und bot daher keinen hinreichenden Schutz vor einer Infektion mit der Yamagata-Linie. In der Influenzasaison 2017/2018 wurden in Deutschland etwa 9.000.000 zusätzliche influenzabedingte Arztkonsultationen und 45.000 Hospitalisierungen berichtet. Neben den Die Autoren C. Kraef und M. v. d. Meirschen habenzugleichenTeilenbeigetragen.

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

“…Between February 27 and June 14, 2020, a total of 166 patients with SARS-CoV-2 infection were treated at the University Medical Center Hamburg-Eppendorf. During the 2017–18 influenza season, 255 patients with laboratory-confirmed seasonal influenza were treated at our center 21 . The baseline characteristics of both groups are listed in Table 1 .…”

“…Remarkably, only four of the 23 deceased seasonal influenza patients in our study cohort were vaccinated against seasonal influenza. Thirdly, given relatively low influenza case numbers throughout the 2019–2020 season, we compared COVID-19 patients to patients diagnosed with seasonal influenza throughout the 2017–18 season, when most laboratory-confirmed influenza cases were attributed to influenza B virus, and mismatch between the trivalent vaccine and the circulating strains occurred 21 . Notably, the rate of patients requiring mechanical ventilation was significantly higher in patients with IAV infections compared to patients with IBV infections.…”

“…We conducted a retrospective observational study at the University Medical Center Hamburg-Eppendorf to compare two patient cohorts: all adult patients with SARS-CoV-2 infection confirmed by RT-PCR between February 27 and June 14, 2020, treated at the University Medical Center Hamburg-Eppendorf. all adult patients with seasonal influenza virus infections confirmed by RT-PCR treated at the University Medical Center Hamburg-Eppendorf between December 25, 2017, and April 8, 2018, which is the definition of the influenza season by the Robert Koch Institute, Germany's national public health institute 20 , 21 . The study was reviewed and approved by the Ethics Committee of the Medical Council of Hamburg (WF-017/18 and WF-052/20).…”

“…all adult patients with seasonal influenza virus infections confirmed by RT-PCR treated at the University Medical Center Hamburg-Eppendorf between December 25, 2017, and April 8, 2018, which is the definition of the influenza season by the Robert Koch Institute, Germany's national public health institute 20 , 21 .…”

“…Clinical information was obtained by retrospective chart review using a standardized case report form, including demographic information, medical history, clinical characteristics, and patient outcome. Detailed information on patients with seasonal influenza treated at our center during the 2017–18 influenza season have been previously published elsewhere 21 . For the current study, COVID-19 and influenza patients were stratified according to whether they were treated as outpatients in our emergency department, were admitted to regular wards of our hospital, or had to be admitted to the intensive care unit (ICU).…”