Management, Husbandry, and Colony Health

Gresham, Vincent C.; Haines, Vicky

doi:10.1016/b978-0-12-380920-9.00021-3

Cited by 10 publications

(3 citation statements)

References 60 publications

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“…Filter top cages are available for mice, rats, guinea pigs, and other small rodents but might not be the standard used in some facilities, particularly for the larger rodents. 9 -12 These filters prevent dispersion of airborne particulates but must allow adequate gas exchange and therefore could allow the transmission of some chemical vapors. 13 -16 Contaminated particulates will likely be a greater concern than vapors after animals have received chemicals.…”

Section: Animal Chemical Control Banding Systemmentioning

confidence: 99%

Chemical Use in Animal Models

2018

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Institutional health and safety programs are responsible for minimizing personnel risk in working with animals that have been administered hazardous chemicals. Regulations and associated guidance are lacking in specific processes for managing these animals. A chemical control banding system categorizes chemicals into bands where each band level is associated with specific control practices. This article describes a general approach to the engineering, administrative, and personal protective equipment practices for developing an animal chemical control banding system. An internal committee should be responsible for conducting the risk assessments to assign chemicals used in animals into band levels, with many factors and resources included to facilitate in this process. The authors provide examples from their home institution where an animal chemical banding system was implemented. Institutions can use this information when designing their own programs, which will likely be unique in consideration of their specific needs and resources.

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Section: Animal Chemical Control Banding Systemmentioning

confidence: 99%

Chemical Use in Animal Models

2018

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“…Guinea pigs have many similarities to humans hormonally, immunologically, and physiologically. Unlike other rodents, and more like primates (including people), guinea pigs are prone to scurvy if they do not receive adequate vitamin C, typically in their diet (Gresham et al, 2012). Guinea pigs are housed similarly to other rodents, although they require more room than the smaller rodents.…”

Section: Guinea Pigsmentioning

confidence: 99%

Commonly Used Animal Models

Hickman

Johnson

Vemulapalli

et al. 2017

Principles of Animal Research

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“…The litter size of 1–6 cubs is small for a rodent [ 8 ] ( figure 1 a , b , d ) and very often chinchillas will carry only one offspring. Furthermore, the gestation period of 105–115 days [ 8 ] is long compared with other established rodent models, such as the guinea pig (59–72 days [ 9 ]), rat (21–23 days [ 10 ]), mouse (19–20 days [ 11 ]), hamster (15.5 days [ 12 ]) and even the approximately threefold larger lagomorph rabbit (29–35 days [ 13 ]; figure 1 a , c , d ). The relatively long gestation period allows higher temporal investigations of the placenta and the fetus, and the small litter size circumvents the challenge of pairing individual measurements on the placenta and fetus over time in longitudinal experiments.…”

Section: Introductionmentioning

confidence: 99%

The chinchilla as a novel animal model of pregnancy

et al. 2017

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Several parameters are important when choosing the most appropriate animal to model human obstetrics, including gestation period, number of fetuses per gestation and placental structure. The domesticated long-tailed chinchilla (Chinchilla lanigera) is a well-suited and appropriate animal model of pregnancy that often will carry only one offspring and has a long gestation period of 105–115 days. Furthermore, the chinchilla placenta is of the haemomonochorial labyrinthine type and is therefore comparable to the human villous haemomonochorial placenta. This proof-of-concept study demonstrated the feasibility in laboratory settings, and demonstrated the potential of the pregnant chinchilla as an animal model for obstetric research and its potential usefulness for non-invasive measurements in the placenta. We demonstrate measurements of the placental and fetal metabolism (demonstrated in vivo by hyperpolarized MRI and in vitro by qPCR analyses), placental vessels (demonstrated ex vivo by contrast-enhanced CT angiography) and overall anatomy (demonstrated in vivo by whole-body CT).

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Management, Husbandry, and Colony Health

Cited by 10 publications

References 60 publications

Chemical Use in Animal Models

Chemical Use in Animal Models

Commonly Used Animal Models

The chinchilla as a novel animal model of pregnancy

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