Management of 13 cases of canine respiratory disease using inhaled corticosteroids

Bexfield, Nick; Foale, Rob; Davison, Lucy; Watson, Penny; Skelly, Barbara; Herrtage, M. E.

doi:10.1111/j.1748-5827.2006.00028.x

Cited by 42 publications

(62 citation statements)

References 35 publications

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“…We hypothesized that a commonly used inhalant GC formulation (ie, fluticasone) used at a clinically relevant dose would have less systemic impact on healthy dogs than PO‐administered GC (ie, prednisone) used at an anti‐inflammatory dosage. We chose what is commonly described as an anti‐inflammatory dosage of prednisone for this study (1 mg/kg/d); this dosage has been suggested specifically for the treatment of chronic bronchitis in dogs 1,2,13 . Although the dosage chosen was typical of an initial dosing scheme, prednisone generally is tapered to the lowest effective dose (often administered on an every other day basis).…”

Section: Discussionmentioning

confidence: 99%

Endocrine and Immunologic Effects of Inhaled Fluticasone Propionate in Healthy Dogs

Cohn

DeClue

Reinero

2008

Veterinary Internal Medicne

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Background: Inhaled glucocorticoids reduce airway inflammation while minimizing systemic effects in several species. Hypothesis: Inhaled fluticasone suppresses the hypothalamic-pituitary-adrenal axis (HPAA), modifies immune function, and induces clinical signs to a lesser extent than PO-administered prednisone in dogs.Animals: Seven healthy adult pet dogs. Methods: Dogs were randomized to 1 of 3 treatment groups in a crossover design: fluticasone propionate (220 mg actuation of a metered dose inhaler delivered via a spacer and mask, q12h), placebo (spacer and mask alone, q12h), or prednisone (1 mg/ kg PO q24h). Each treatment was administered for 3 weeks followed by a 4-week washout. Appetite, attitude, and water consumption were recorded during the last week of each treatment period. Urine cortisol : creatinine ratios, ACTH stimulation tests, white blood cell counts, lymphocyte phenotype, and serum IgM and IgA concentrations were recorded at each baseline and after the last day of each treatment. Clinical observations were expressed descriptively. Friedman's test was applied to all data comparisons. Pairwise comparisons were made with a mixed model analysis when data were normally distributed, whereas signed rank tests were used otherwise (significance P-value o.01).Results: Appetite and water consumption increased during prednisone treatment. Peak serum cortisol concentrations post-ACTH were significantly decreased in prednisone-and fluticasone-treated dogs compared with placebo (prednisone 4 fluticasone). Serum IgM concentrations were significantly decreased in dogs treated with prednisone.Conclusions and Clinical Importance: As used, fluticasone suppresses the HPAA to a lesser extent than prednisone and may avert systemic signs associated with PO-administered glucocorticoids in dogs.

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Section: Discussionmentioning

confidence: 99%

Endocrine and Immunologic Effects of Inhaled Fluticasone Propionate in Healthy Dogs

Cohn

DeClue

Reinero

2008

Veterinary Internal Medicne

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“…In group 3a disorders, recommended treatment is primarily symptomatic and includes cough suppression, sedation, oxygen supplementation, and, when present, control of secondary infection and inflammation. Specific examples may include, but are not limited to, glucocorticoids, opioids or other sedatives, antimicrobials, and antitussives . For management of severe tracheal collapse, placement of an intraluminal stent can be considered …”

Section: Treatmentmentioning

confidence: 99%

“…Whole lung lavage has been described to treat pulmonary alveolar proteinosis . Corticosteroids are the primary treatment for eosinophilic lung disease In dogs with group 3b2 disorders in which infection underlies pathology, appropriate antimicrobials are recommended.…”

Section: Treatmentmentioning

confidence: 99%

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Reinero

Visser

Kellihan

et al. 2020

Veterinary Internal Medicne

192

383

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Pulmonary hypertension (PH), defined by increased pressure within the pulmonary vasculature, is a hemodynamic and pathophysiologic state present in a wide variety of cardiovascular, respiratory, and systemic diseases. The purpose of this consensus statement is to provide a multidisciplinary approach to guidelines for the diagnosis, classification, treatment, and monitoring of PH in dogs. Comprehensive evaluation including consideration of signalment, clinical signs, echocardiographic parameters, and results of other diagnostic tests supports the diagnosis of PH and allows identification of associated underlying conditions. Dogs with PH can be classified into the following 6 groups: group 1, pulmonary arterial hypertension; group 2, left heart disease; group 3, respiratory disease/hypoxia; group 4, pulmonary emboli/pulmonary thrombi/pulmonary thromboemboli; group 5, parasitic disease (Dirofilaria and Angiostrongylus); and group 6, disorders that are multifactorial or with unclear mechanisms. The approach to treatment of PH focuses on strategies to decrease the risk of progression, complications, or both, recommendations to target underlying diseases or factors contributing to PH, and PH‐specific treatments. Dogs with PH should be monitored for improvement, static condition, or progression, and any identified underlying disorder should be addressed and monitored simultaneously.

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“…The insertion of a 16α-hydroxy group decreases mineralocorticoid activity and leads to the synthesis of triamcinolone (which also has a 9α-fluoro group). In particular the use of budesonide as an oral drug for the treatment of inflammatory bowel disease and budesonide and fluticasone propionate as inhaled medications for chronic inflammatory airway disease has recently gained popularity in dogs and cats (Bexfield et al, 2006;Padrid, 2006;Dye et al, 2013;Galler et al, 2013;Pietra et al, 2013). The effects of glucocorticoids are dose dependent, and they are classified according to their potency in relation to the potency of cortisol (Table 14-1).…”

Section: Chemistry Of Glucocorticoids and Structure-activity Relationmentioning

confidence: 99%

Glucocorticoid Therapy

Reusch¹

2015

Canine and Feline Endocrinology

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Management of 13 cases of canine respiratory disease using inhaled corticosteroids

Abstract: Inhaled corticosteroids were used for the management of chronic bronchitis and eosinophilic bronchopneumopathy in 13 dogs, and these may have the advantage of reducing side effects associated with oral corticosteroids.

Cited by 42 publications

References 35 publications

Endocrine and Immunologic Effects of Inhaled Fluticasone Propionate in Healthy Dogs

Endocrine and Immunologic Effects of Inhaled Fluticasone Propionate in Healthy Dogs

ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs

Glucocorticoid Therapy

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