Management of a case of accidental intrathecal administration of meglumine diatrizoate

Chirumamilla, Vikramaditya; Dholke, Harshal; Patki, Jayashree

doi:10.4103/0019-5049.98795

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…She progressively developed ascending, rigid, jerky, intermittent involuntary movements of both lower limbs. She had 60 ml CSF drainage, which successfully saved the patient from potentially life‐threatening sequelae . Nakazawa reported two cases of successful management of patients with accidental intrathecal amidetrizoate (Urografin) by CSF lavage and intravenous administration of thiopentone .…”

Section: Contrast Agentsmentioning

confidence: 99%

Inadvertent intrathecal injections and best practice management

Liu

Tariq

Liu

et al. 2016

Acta Anaesthesiol Scand

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The intrathecal space has become an important anatomic site for medical intervention not only in anesthesia practice, but also in many other medical specialties. Undesired/inadvertent intrathecal injections (UII) are generally rare. There is tremendous variation in reported inadvertent administrations via an intrathecal route in the literature, mainly as individual cases and very small case-series reports. This review aims to identify potential sources of UII, its clinical presentations, and appropriate management. The inadvertent injectants are classified as anesthetic agents and pain medicines, chemotherapeutics, radiological contrast agents, antibiotics and corticosteroids, and miscellaneous chemical agents such as tranexamic acid. The clinical effects of UII are dependent upon inadvertent injectant(s) and dose being administered intrathecally, and can range from no adverse effect to profound neurological consequences and/or death. Prompt cerebrospinal fluid (CSF) lavage and cardiopulmonary support seem to be the mainstay of treatment. If serious consequences are anticipated, CSF lavage could be lifesaving. This review additionally provides some options for comprehensive management and preventing strategies.

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Section: Contrast Agentsmentioning

confidence: 99%