Management of a Challenging Arteriovenous Malformation of the Scalp and Orbit in a Patient With Polycystic Kidney Disease

Bit, Nupur; Vidyasagaran, T.; Amalorpavanathan, J.; Balakrishnan, Thalaivirithan Margabandu; Narayanan, Sritharan

doi:10.1016/j.avsg.2012.04.010

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…The concept of regulating flap, that reconstruction using a free flap controls the recurrence or regrowth after resection of AVM, has been proposed. However, no report has evaluated whether free flaps and other flap types clearly prevent the recurrence or regrowth compared with skin grafts…”

Section: Resultsmentioning

confidence: 99%

Japanese clinical practice guidelines for vascular anomalies 2017

Mimura

Akita

Fujino

et al. 2020

Pediatrics International

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The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were decided based on the important clinical issues. For document retrieval, key words for literature searches were set for each CQ and literature published from 1980 to the end of September 2014 was searched in Pubmed, Cochrane Library, and Japana Centra Revuo Medicina (JCRM). The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution System (MINDS) technique. A total of 33 CQs were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy, and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, and pathological diagnosis deciding the diagnosis. Thus, the Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 have been prepared as the evidence‐based guidelines for the management of vascular anomalies.

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Section: Resultsmentioning

confidence: 99%

Japanese clinical practice guidelines for vascular anomalies 2017

Mimura

Akita

Fujino

et al. 2020

Pediatrics International

View full text Add to dashboard Cite

show abstract

“…The concept of a regulating flap, that reconstruction using a free flap controls the recurrence or regrowth after resection of AVM, has been proposed. However, no report has evaluated whether free flaps and other flap types clearly prevent the recurrence or regrowth compared with skin grafts…”

Section: Resultsmentioning

confidence: 99%

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Mimura

Akita

Fujino

et al. 2020

The Journal of Dermatology

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The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety and systematizing treatment, employing evidence-based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQ) were decided based on the important clinical issues. For document retrieval, key words for published work searches were set for each CQ, and work published from 1980 to the end of September 2014 was searched in PubMed, Cochrane Library and Japana Centra Revuo Medicina databases. The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution System technique. A total of 33 CQ were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, and pathological diagnosis deciding the diagnosis. Thus, the Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 have been prepared as the evidence-based guidelines for the management of vascular anomalies.

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“…In ECs lacking primary cilia, we predict reduced translocation of the p-SMAD1/5/8 and SMAD4 complex to the nucleus and reduced transcription of their target genes ( Taylor and Khachigian, 2000 ; Li et al, 2011 ). 4- There have been a limited number of isolated case reports of ciliopathy patients presenting with AVMs and arteriovenous fistulas in the brain, the cervix and the lungs ( Banerjee and Rana, 1976 ; Proesmans et al, 1982 ; Tsuruda et al, 1996 ; Nishida et al, 2002 ; Bit et al, 2012 ; Grieb et al, 2014 ; Aregullin et al, 2019 ). Nonetheless, there does not appear to be a consistently established link between ciliopathies and AVMs or other vascular malformations in animal models or in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia

Eisa-Beygi

Burrows²,

Link³

2022

Front. Cell Dev. Biol.

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Hereditary hemorrhagic telangiectasia (HHT) is associated with defective capillary network, leading to dilated superficial vessels and arteriovenous malformations (AVMs) in which arteries connect directly to the veins. Loss or haploinsufficiency of components of TGF-β signaling, ALK1, ENG, SMAD4, and BMP9, have been implicated in the pathogenesis AVMs. Emerging evidence suggests that the inability of endothelial cells to detect, transduce and respond to blood flow, during early development, is an underpinning of AVM pathogenesis. Therefore, components of endothelial flow detection may be instrumental in potentiating TGF-β signaling in perfused blood vessels. Here, we argue that endothelial cilium, a microtubule-based and flow-sensitive organelle, serves as a signaling hub by coupling early flow detection with potentiation of the canonical TGF-β signaling in nascent endothelial cells. Emerging evidence from animal models suggest a role for primary cilia in mediating vascular development. We reason, on recent observations, that endothelial cilia are crucial for vascular development and that embryonic loss of endothelial cilia will curtail TGF-β signaling, leading to associated defects in arteriovenous development and impaired vascular stability. Loss or dysfunction of endothelial primary cilia may be implicated in the genesis of AVMs due, in part, to inhibition of ALK1/SMAD4 signaling. We speculate that AVMs constitute part of the increasing spectrum of ciliopathy-associated vascular defects.

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Management of a Challenging Arteriovenous Malformation of the Scalp and Orbit in a Patient With Polycystic Kidney Disease

Cited by 3 publications

References 2 publications

Japanese clinical practice guidelines for vascular anomalies 2017

Japanese clinical practice guidelines for vascular anomalies 2017

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Endothelial cilia dysfunction in pathogenesis of hereditary hemorrhagic telangiectasia

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