This review focuses on the design and architecture of operating theater, operating rooms, equipments, and safe surgery. We reviewed the physical environmental features associated with patient and staff safety and outcomes. Methods: A literature search was conducted using PubMed and SciElo databases. The inclusion criteria included peer-reviewed journal articles that reported aspects of the physical environment of operating theater, equipments and safe surgery. The review included studies, guide lines as well as best practice articles. Results: The main themes that emerged included design-related factors, architecture, ventilation, temperature and humidity, lighting, electricity, safety and materials. Some environmental threats to patient safety should include, clutter, poor air quality, surface contamination, and noise. Equipments, installations and rules of safe surgery are described. Conclusion: This literature review provides an overview of the complexity of a surgical theater. Designfocused topic areas are supported by guidelines followed by architects and designers. This review identified that surgical theaters are built with pre-established guidelines and in them everything is done for the safety and well-being of the integrated team and patients.