Management of Acne

Gollnick, Harald; Cunliffe, W. J.; Berson, Diane; Dréno, Brigitte; Finlay, A.Y.; Leyden, James J.; Shalita, Alan R.; Thiboutot, Diane

doi:10.1067/mjd.2003.618

Cited by 667 publications

(202 citation statements)

References 205 publications

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“…However acne relapses in only about 30% of those patients. This has been attributed to additional methods of action [3]. The 1,450-nm diode laser might also have additional modes of action in the treatment of acne vulgaris, such as decreasing P. acnes.…”

Section: Discussionmentioning

confidence: 99%

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The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

2007

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Background and Objectives: Over the last several years, several light-based systems have been employed for the treatment of acne vulgaris. The 1,450-nm diode laser has been shown to improve acne, and this has been suggested to be due to effects on sebaceous glands. However, an effect on sebum production has not been demonstrated. The objective of this study was to evaluate if the 1,450-nm diode laser indeed reduces sebum production. Study Design/Materials and Methods: Eight patients with a history of acne were recruited and treated with the 1,450-nm diode laser on the right side of the nose over a 6-week period, for a total of three treatments. Sebum production was quantified using the Sebutape method. Results: The number of sebum-producing follicles was reduced by 8.5 and 16.7% at weeks 4 and 6, respectively (P<0.05). A significant reduction in total collected sebum (À18%) was observed at week 6. Conclusion: This data suggests that the clinical effectiveness of the 1,450-nm diode laser may be based, at least in part, on its effects on sebaceous glands, with subsequent reduction in sebum production.

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Section: Discussionmentioning

confidence: 99%

“…Traditional therapies target the following pathogenic factors: follicular hyperkeratinization, bacterial infection with Propionibacterium acnes (P. acnes), sebum production, and inflammation [3]. Most of the current therapies for acne vulgaris target one or more of these pathogenic factors.…”

Section: Introductionmentioning

confidence: 99%

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

2007

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“…53 Their most common adverse effects include burning, stinging, dryness, and scaling. 15 These effects may be reduced by initiating treatment with the lowest strength, typically sufficient to treat mild acne, or by recommending regular use of a moisturizer. Patients should be instructed not to spot-treat but rather to use a pea-size amount to cover the entire face.…”

Section: Prescription Treatment Options: Single Agents Topical Retinoidsmentioning

confidence: 99%

“…48 Tolerability may be further improved by the use of a noncomedogenic moisturizer that includes a sunscreen. 15,38 48 Other topical retinoid alternatives to tretinoin include adapalene and tazarotene. Adapalene, a distinct retinoid that is generally well tolerated, is available in cream, gel, and lotion formulations.…”

Section: Prescription Treatment Options: Single Agents Topical Retinoidsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

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INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, and association of acne with systemic pathology differs by age of presentation. Current acknowledged guidelines for the diagnosis and management of pediatric acne are lacking, and there are variations in management across the spectrum of primary and specialty care. The American Acne and Rosacea Society convened a panel of pediatric dermatologists, pediatricians, and dermatologists with expertise in acne to develop recommendations for the management of pediatric acne and evidence-based treatment algorithms. METHODS: Ten major topic areas in the diagnosis and treatment of pediatric acne were identified. A thorough literature search was performed and articles identified, reviewed, and assessed for evidence grading. Each topic area was assigned to 2 expert reviewers who developed and presented summaries and recommendations for critique and editing. Furthermore, the Strength of Recommendation Taxonomy, including ratings for the strength of recommendation for a body of evidence, was used throughout for the consensus recommendations for the evaluation and management of pediatric acne. Practical evidence-based treatment algorithms also were developed. RESULTS: Recommendations were put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status. Treatment considerations include the use of over-the-counter products, topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, and isotretinoin. Simplified treatment algorithms and recommendations are presented in detail for adolescent, preadolescent, infantile, and neonatal acne. Other considerations, including psychosocial effects of acne, adherence to treatment regimens, and the role of diet and acne, also are discussed. CONCLUSIONS: These expert recommendations by the American Acne and Rosacea Society as reviewed and endorsed by the American Academy of Pediatrics constitute the first detailed, evidence-based clinical guidelines for the management of pediatric acne including issues of special concern when treating pediatric patients.

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“…The human skin is densely populated with resident microbiota, which is mainly commensal microorganisms, such as Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus (Thiboutot, 2002;Gollnick et al, 2003;Nagy et al, 2006). The bacteria P. acnes and S. epidermidis have been recognized as the major cause of acne comedos (Leyden and Klingman, 1976).…”

Section: Use Of Indonesian Medicinal Plants In Antibacterial Therapiesmentioning

confidence: 99%

Use of Indonesian Medicinal Plants Products Against Acne

Batubara

Mitsunaga

2013

RAS

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Indonesia contains a diverse range of cultures and plants. For a long time, Jamu, which is a traditional Indonesian medicine, had been used for beauty and human health in Indonesia. In this study, Indonesian medicinal plants used for skin care were examined, and the relevant information was update to incorporate anti-acne therapies. The anti-acne mechanisms included antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus, bacterial lipase inhibition, antioxidant, and anti-inflammatory activities. Most of the Indonesian medicinal plants used in skin care showed anti-acne activity that utilized et least 2 of these mechanisms. The compounds isolated from the Indonesian traditional medicinal plants related to the anti-acne activities are also discussed. In conclusion, more research on Indonesian medicinal plants is needed.

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Management of Acne

Cited by 667 publications

References 205 publications

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

The 1,450‐nm diode laser reduces sebum production in facial skin: A possible mode of action of its effectiveness for the treatment of acne vulgaris

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

Use of Indonesian Medicinal Plants Products Against Acne

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