Management of advanced stages of Osteonecrosis of the Jaws due to Bisphosphonates: Report of two cases

Abstract

Bisphosphonates are a class of drugs used to strengthen bone. They are indicated in the treatment of osteoporosis and Paget's disease as well as malignant pathologies such as breast cancer, bone metastases. The examples of medications bisphosphonates includes Aledronate, Ibandronate, Incadronate, Olpadronate, Pamidronate, Risedronate, and Zoledronate. One of the most important complications of bisphosphonates is osteonecrosis of the jaws which alters the quality of life of the patient and is all the more difficult to manage as osteonecrosis is advanced. This paper describes two cases of advanced osteonecrosis whose management was very difficult leading to a recurrence of this complication.