“…Alcoholic liver injury caused by chronic alcohol consumption has become a major global public health problem, 1,2 covering a range of developmental stages of alcoholic liver diseases from simple hepatic steatosis and steatohepatitis to end-stage organ disease (cirrhosis/fibrosis). [3][4][5][6] Commonly, the consumed alcohol is metabolized into acetaldehyde by alcohol dehydrogenase, and further metabolized into acetic acid by aldehyde dehydrogenase. 7,8 However, long-term alcohol intake can ultimately lead to the accumulation of acetaldehyde and production of reactive oxygen species.…”