Management of androgenetic alopecia: a review

Abstract

<p class="abstract">Androgenetic alopecia is a patterned hair loss disorder affecting approximately 73% of men and 57% of women in their lifetime, this affection can cause psychological effects like low self-stem and depression diminishing the quality of life. Currently, finasteride and minoxidil are the only two drugs approved by the food and drug administration (FDA), and devices of low-level laser therapy are FDA cleared. Alternative therapies for androgenetic alopecia treatment include a drug like dutasteride, botulinum toxin A, cell-based therapies like adipose-derived stem cell-conditioned medium and platelet-rich plasma protocols. A combination of two or more therapies can be found in the literature, the general consent indicates that any combination has higher efficiency than a single therapy. Finasteride is in less use due to the related sexual side effects, some adjuvant techniques have emerged to improve the delivery and effectiveness of minoxidil, i.e. micro needling. The surgical approach is mainly focused on hair transplant surgery, which offers relatively less invasive procedures and is a more suitable option for long time results, however, it is expensive. Recently, drug-assisted delivery techniques have emerged to improve the efficiency of conventional drugs; transdermal drug delivery through ultrasound pressure waves means creating diffusion channels, increasing skin permeability and stimulating cell differentiation and growth factor utilization along with minoxidil absorption. Another approach for drug-assisted delivery is the embodiment of finasteride in polymer-based microspheres aiming for a sustained and controlled delivery, which can be beneficial to reduce the regular doses decreasing adverse effects.</p>

Breaking bald: Unraveling the mysteries of hair loss and modern treatments

“…The effectiveness of finasteride in countering male pattern baldness is also worth noting. 6 Finasteride stands as another medication greenlit by the US FDA for managing male pattern baldness. Studies have indicated that finasteride proficiently obstructs the enzyme responsible for converting testosterone into dihydrotestosterone, a factor known for advancing male pattern baldness.…”

“…5 Moreover, the topical application of minoxidil has gained approval from the US FDA for both men and women, rendering it a viable treatment avenue for androgenic hair loss. 2,6,7 In addition to minoxidil, another medication sanctioned by the US FDA for addressing androgenic hair loss in men is finasteride. 7 The emotional and social ramifications of hair loss are frequently underestimated, as the medical dimensions of the underlying conditions are generally perceived as less severe.…”