Management of Antidepressant Therapy–Induced Sexual Dysfunction in Women

Lurati, Ann R.

doi:10.1016/j.nurpra.2022.01.002

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…There is still a need for safe, affordable, and easily available remedies, even in cases when women’s sexual problems can be treated with certain pharmaceutical approaches [ 15 , 16 ]. However, certain antidepressants can cause sexual dysfunction, making it more challenging to address sexual issues in patients also dealing with major depressive disorder [ 17 ]. The development of sexual dysfunction following selective serotonin reuptake inhibitor medications was confirmed in women before [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial

Torkaman,

Meybodi,

Kheradmand

et al. 2024

BMC Psychiatry

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Background While some evidence suggests that l-arginine may improve sexual function and alleviate depression, it has not been investigated in women with depression to assess both its effects on the depression and sexual function concurrently. Methods Patients who had received a diagnosis of major depressive disorder, as determined by predetermined inclusion and exclusion criteria, were enrolled in this triple-blind clinical trial. Patients were divided into two groups: group A, received L-arginine 1 gram twice daily, and group B, received a placebo for four weeks. They were evaluated at baseline, after four and eight weeks with the Hamilton Depression Rating Scale (HDRS), and Rosen’s questionnaire or Female Sexual Function Index (FSFI). Results A decrease in the severity of depression was observed in all patients, which was determined due to Hamilton’s questionnaire (P-value < 0.001). During the time in group A, FSFI increased. Based on the FSFI questionnaire, they had improvement in some domains, including the lubrication index and orgasm index, which significantly changed in the eighth week compared to the baseline (P-value < 0.05). However, these two indicators did not change statistically significantly compared to the placebo group. Conclusion L-arginine supplementation can improve sexual function, particularly lubrication and orgasm, and mood in women with depression, with minimal side effects observed. Additional research is necessary to validate these results by examining the effects of higher dosages, extended durations, and larger populations of depressed patients. Trial registration Iranian Registry of Clinical Trial: IRCT20100127003210N26.

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