Management of antiepileptic drug–induced nutrition-related adverse effects

Safahani, Maryam; Aligholi, Hadi; Asadi‐Pooya, Ali A.

doi:10.1007/s10072-020-04573-5

Cited by 10 publications

(10 citation statements)

References 107 publications

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“…Self-imposed dietary restrictions may contribute to the inadequate vitamin D intake reported in individuals with ASD [ 8 , 9 , 12 , 20 ]. Furthermore, therapeutic dietary restrictions such as a casein-free diet [ 131 ] and long-term administration of antiepileptic drugs [ 132 ] in some ASD cases may also contribute to vitamin D deficiency.…”

Section: Vitaminsmentioning

confidence: 99%

The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder

Indika

Frye²,

Rossignol³

et al. 2023

JPM

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Children with autism spectrum disorder may exhibit nutritional deficiencies due to reduced intake, genetic variants, autoantibodies interfering with vitamin transport, and the accumulation of toxic compounds that consume vitamins. Importantly, vitamins and metal ions are essential for several metabolic pathways and for neurotransmitter functioning. The therapeutic benefits of supplementing vitamins, minerals (Zinc, Magnesium, Molybdenum, and Selenium), and other cofactors (coenzyme Q10, alpha-lipoic acid, and tetrahydrobiopterin) are mediated through their cofactor as well as non-cofactor functions. Interestingly, some vitamins can be safely administered at levels far above the dose typically used to correct the deficiency and exert effects beyond their functional role as enzyme cofactors. Moreover, the interrelationships between these nutrients can be leveraged to obtain synergistic effects using combinations. The present review discusses the current evidence for using vitamins, minerals, and cofactors in autism spectrum disorder, the rationale behind their use, and the prospects for future use.

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Section: Vitaminsmentioning

confidence: 99%

The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder

Indika

Frye²,

Rossignol³

et al. 2023

JPM

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“…Interactions between ASMs and comestibles (ie, foods and drinks) are the important and often under‐recognized issue in clinical practice 4 . In addition, interactions between disease (ie, epilepsy) and comestibles are even more under‐recognized by healthcare professionals, and at the same time more of a concern for PWE and their caregivers 5 …”

Section: Introductionmentioning

confidence: 99%

Caffeinated drinks, fruit juices, and epilepsy: A systematic review

Asadi‐Pooya

Zeraatpisheh

Rostaminejad

et al. 2021

Acta Neuro Scandinavica

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The aim of this systematic review was to provide the required information regarding different aspects of the relationship between epilepsy/antiseizure medications and non‐alcoholic drinks. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement were followed. MEDLINE and Scopus from the inception until 7 August 2021 were systematically searched. These key words were used: “epilepsy” OR “seizure” OR “antiepileptic” OR “antiseizure” OR “anticonvulsant” AND “coffee” OR “tea” OR “soda” OR “juice” OR “drink” OR “cola” OR “diet” (35 key word combinations). The primary search yielded 21 458 publications (PubMed, n = 4778; Scopus, n = 16 680). Only 50 studies met all the inclusion criteria and were included in the current systematic review. In total, 17 articles investigated various non‐alcoholic drinks in human studies, 11 studies were case reports/series, and 22 articles were animal/in vitro studies. None of the studies provided a class 1 of evidence. There is limited evidence suggesting that certain drinks (eg, caffeinated energy drinks) might trigger seizures. Patients with epilepsy should avoid excessive consumption of certain fruit juices (eg, grapefruit, lime, pomegranate, kinnow, and star fruit) and caffeinated drinks. However, daily coffee and tea intake can be part of a healthy balanced diet, and their consumption does not need to be stopped in patients with epilepsy. Coffee/tea consumption is not harmful if consumed at levels of 200 mg (caffeine) in one sitting (about 2½ cups of coffee) or 400 mg daily (about five cups of coffee).

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“…

Drug-micronutrient interactions l ANALYSIS ■ underdiagnosed. 9,[10][11][12] This clinical blind spot for micronutrient-related adverse drug effects reduces overall pharmacotherapeutic risk awareness. 13

Contribution of micronutrient status to risk from drugsThe impact of drug-micronutrient interactions is magnified in patients with already compromised micronutrient status, for example owing to low dietary intakes or chronic illness (including cancer and chronic malabsorption syndrome).

…”

mentioning

confidence: 99%

“…Drug-micronutrient interactions l ANALYSIS ■ underdiagnosed. 9,[10][11][12] This clinical blind spot for micronutrient-related adverse drug effects reduces overall pharmacotherapeutic risk awareness. 13…”

mentioning

confidence: 99%