Management of Antipsychotic-Induced Weight Gain: Prospective Naturalistic Study of the Effectiveness of a Supervised Exercise Programme

Poulin, Michelle; Chaput, Jean‐Philippe; Simard, Véronique; Vincent, Pierre; Bernier, Joëlle; Gauthier, Yvan; Lanctôt, Guy; Saindon, Jacynthe; Vincent, Annick; Gagnon, Solange; Tremblay, Angelo

doi:10.1080/00048670701689428

Cited by 117 publications

(94 citation statements)

References 50 publications

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“…15,16 In addition to resistance training, previous studies of patients with schizophrenia have used a combination of aerobic and resistance exercises in the same session, which is known as concurrent exercise. 5,17,18 Marzolini et al examined concurrent exercise twice a week for 12 weeks among patients with schizophrenia and found that this type of training improves general mental health and generally increases muscle strength. 5 Scheewe et al recently found similar results, with improvement of schizophrenia symptoms after 6 months of concurrent training.…”

Section: Introductionmentioning

confidence: 99%

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

Silva

Cassilhas

Àttux

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. Methods: In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9). Symptoms, quality of life, strength, and other variables were assessed. Results: A significant time-by-group interaction was found for the RESEX and CONCEX groups on the Positive and Negative Syndrome Scale (PANSS) total score for disease symptoms (p = 0.007), positive symptoms (p = 0.003), and on the arm extension one-repetition maximum (1RM) test (p = 0.016). In addition, significant improvements on negative symptoms (p = 0.027), on the role-physical domain of the Short Form-36 Health Survey (p = 0.019), and on the chest press 1RM test (p = 0.040) were observed in the RESEX group. No changes were observed for the other variables investigated. Conclusions: In this sample of patients with schizophrenia, 20 weeks of resistance or concurrent exercise program improved disease symptoms, strength, and quality of life. ClinicalTrials.gov: NCT01674543.

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Section: Introductionmentioning

confidence: 99%

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

Silva

Cassilhas

Àttux

et al. 2015

Rev. Bras. Psiquiatr.

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“…Comprehensive weight management programmes, including diet, exercise and counselling on lifestyle modifications, can also prove helpful in reducing weight, as shown by a naturalistic study and an RCT [Kwon et al 2006;Poulin et al 2007]. However, another naturalistic study showed no significant outcomes following a similar nurse-led programme in patients with schizophrenia spectrum disorders [Ohlsen et al 2004].…”

Section: Description and Discussion Of Studiesmentioning

confidence: 99%

Interventions for the metabolic syndrome in schizophrenia: a review

Papanastasiou¹

2012

Therapeutic Advances in Endocrinology

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Abstract:The metabolic syndrome (MetS) is an increasingly prevalent condition in people with schizophrenia. It remains highly prevalent in the general population in developed countries, but recently health promotion campaigns and greater awareness of the high associated mortality rates have resulted in improvements in the rates of cardiovascular risk factors. This is not the case for people with schizophrenia who continue to have more than twice the rates of MetS and significantly higher mortality rates than the general population. Various behavioural and pharmacological interventions have been used to improve conditions that are linked to MetS, mainly smoking and obesity. This review aims to provide an update of the latest knowledge about the behavioural, pharmacological and other interventions that might help to combat this life-threatening problem in people with schizophrenia.

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“…Cinq études ont inclus le profil lipidique comme mesure d'effet (29,4 %). Seule l'étude de Poulin et al (2007) relève un impact différentiel de leur programme sur le profil lipidique des patients. Après 18 mois, leurs résultats démontrent une amélioration du profil lipidique de leurs participants en ce qui a trait au cholestérol total, du cholestérol LDL et HDL et sur le taux de triglycérides.…”

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Efficacité des programmes de modifications des habitudes de vie pour la gestion de poids des personnes avec des troubles psychiatriques

Bélanger

Provencher

Shriqui

2013

smq

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Un gain de poids significatif est associé à l’utilisation des antipsychotiques atypiques, des stabilisateurs de l’humeur et des antidépresseurs employés seuls ou en combinaison. Les personnes avec des troubles psychiatriques sont plus à risque de souffrir d’obésité et du syndrome métabolique que la population générale. Une approche prometteuse pour limiter les conséquences physiques et psychologiques du gain de poids est la modification des habitudes de vie. Nous avons révisé la littérature afin de détailler l’impact de ces programmes sur différentes mesures d’effet. Douze des dix-sept études recensées rapportent un impact significatif de leur programme sur le poids en comparaison des soins usuels généralement offerts aux personnes avec des troubles psychiatriques. L’importance de la mise en place de ces programmes pour les patients psychiatriques en externe est soulignée.Significant weight gain is common in patients with psychiatric disorders taking antipsychotics, mood stabilisers and/or antidepressants. Psychiatric patients are at a higher risk of suffering from obesity and from the metabolic syndrome than the general population. One promising alternative to limiting weight gain involves modifying lifestyle behaviors. We reviewed the literature on behavioral weight management programs for this clientele. Of the 17 identified studies, 12 reported a significant impact of the program on weight gain compared to usual care. The importance of offering weight management programs to psychiatric patients in outpatient settings is stressed

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Management of Antipsychotic-Induced Weight Gain: Prospective Naturalistic Study of the Effectiveness of a Supervised Exercise Programme

Abstract: Bodyweight and metabolic risk profile in patients receiving atypical antipsychotic medications can be effectively managed with a weight control programme including physical activity.

Cited by 117 publications

References 50 publications

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

Interventions for the metabolic syndrome in schizophrenia: a review

Efficacité des programmes de modifications des habitudes de vie pour la gestion de poids des personnes avec des troubles psychiatriques

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