Apico-marginal defects are localized bony defects encompassing the total root length. The presence of apico-marginal defects has accounted for the failure of endodontic treatment in many cases. The best treatment option for such defect is to perform endodontic surgery using Guided Tissue Regeneration (GTR) membranes. Recently, platelet-rich fibrin (PRF), has been suggested as a better alternative to the conventional practice of using guided tissue regeneration (GTR) barrier membranes for the treatment of these defects. This case report presents clinical management of apico-marginal defect allied with extensive peri-radicular destruction in a maxillary central incisor subjected to periapical surgery using sticky bone and PRF as a barrier membrane. The patient was followed up for 1 year. Clinically, there was a reduction in probing pocket depth, and an increase in attached gingiva, and radiographically a resolution of periapical radiolucency and a significant amount of bone fill was evident.