Management of arterial hypertension: Challenges and opportunities

Silva, Beatriz V.; Sousa, Ana Catarina; Caldeira, Daniel; Abreu, Ana; Pinto, Fausto J.

doi:10.1002/clc.23938

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…O ganho de peso está intimamente relacionado à hipertensão e suas causas secundárias, como a apneia obstrutiva do sono (SILVA et al, 2022). O controle de peso tem importância hipotensora e melhora a eficácia dos anti-hipertensivos, devendo ser alcançada por abordagem multidisciplinar que envolva acompanhamento nutricional e atividade física regular (SILVA et al, 2022).…”

Section: Controle De Peso E Atividade Físicaunclassified

“…De modo geral, a atividade física regular confere menor morbimortalidade cardiovascular. Observa-se que, apesar do treinamento de moderada a alta intensidade provocar maior redução dos níveis de PA, a atividade física regular, mesmo em baixa intensidade, quando comparada aos indivíduos não ativos, está associada à redução de mortalidade (DHUNGANA et al, 2022;SILVA et al, 2022).…”

Section: Controle De Peso E Atividade Físicaunclassified

“…Há interação linear entre consumo de álcool e elevação pressórica, sendo o consumo abusivo associado à maior prevalência de hipertensão. Espera-se redução de 3-4 mmHg na PAS com abstinência completa ou redução da ingesta para menos de 2 doses por dia com 2 dias de folga por semana (SILVA et al, 2022). Segundo a OMS, não existe padrão seguro de consumo de álcool.…”

Section: Redução Do áLcool E Cessação Do Tabagismounclassified

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Hipertensão Arterial Sistêmica: Abordagem Clínico-Epidemiológica

GARCIA¹,

PEIXOTO²,

SILVA³

et al. 2023

Cardiologia Teoria E Prática - Edição VII

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Section: Controle De Peso E Atividade Físicaunclassified

Section: Redução Do áLcool E Cessação Do Tabagismounclassified

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Hipertensão Arterial Sistêmica: Abordagem Clínico-Epidemiológica

GARCIA¹,

PEIXOTO²,

SILVA³

et al. 2023

Cardiologia Teoria E Prática - Edição VII

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“…Із розвитком сучасних методів діагностики, зокрема, методів лабораторної діагностики, вдалося дослідити різні механізми розвитку артеріальної гіпертензії, зокрема порушення функціонування ендокринної, нервової системи, а також різноманітні порушення метаболічних процесів. Всі ці зміни можуть відбуватися паралельно, взаємопідсилюючи один одного, що і призводить до розвитку даного захворювання [2,3].…”

Section: вступunclassified

The role of insulin resistance and oxidative stress in the mechanisms of arterial hypertension development

Кучменко,

Гавій,

Шейко

et al. 2023

NCBio

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Hypertension is a pathophysiological process associated with morphological and functional disorders in cellular structures that lead to progressive imbalance of the cardiovascular system of the organism. The purpose of the study was to study the role of insulin resistance and oxidative stress in the mechanisms of development of arterial hypertension. The study included 55 patients with controlled arterial hypertension aged 57.3 ± 4.5 years. The content of glucose, insulin, products of free radical oxidation of lipids and proteins, and the activity of antioxidant protection enzymes were determined in the patients' blood. According to the results of determining the content of glucose, insulin and calculating the HOMA index, patients were divided into two groups - patients with controlled arterial hypertension without and with insulin resistance. An increase (p ≤ 0.05) in the content of primary (diene conjugates) and secondary (TBA-positive products) lipid oxidation products, protein oxidation products in the blood serum of patients with arterial hypertension without and with insulin resistance was demonstrated. Higher levels of lipid and protein oxidation products (p ≤ 0.05) were observed in patients with hypertension and insulin resistance compared to patients with hypertension without insulin resistance. A decrease (p ≤ 0.05) in the activity of antioxidant protection enzymes - superoxide dismutase and catalase in patients with arterial hypertension without and with insulin resistance was also shown. In patients with arterial hypertension and insulin resistance, the decrease in the activity of these enzymes was significantly greater (p ≤ 0.05) compared to patients with arterial hypertension without insulin resistance. Taking into account the obtained results, it is necessary to distinguish between patients diagnosed with hypertension, depending on the presence or absence of insulin resistance. Patients with hypertension and insulin resistance require a complex approach to treatment, as they have more profound changes in metabolic processes, in particular, oxidative metabolism. Insulin resistance and arterial hypertension are mutually reinforcing, therefore, for effective treatment and prevention of further complications, it is necessary to combine means and approaches to influence each of these links to more effectively prevent the development of metabolic disorders in the orgsnism.

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“…HTN is an established risk factor for stroke, ischemic heart disease (Burnier & Egan, 2019), and renal dysfunction (Hall et al, 2019). HTN is one of the main causes of cardiovascular mortality and morbidity worldwide, it is preventable and affects over one billion adults, and the most common reason for medical consultation (Valente Silva et al, 2022). Diet and lifestyle modification can regulate BP to control HTN or its associated outcomes (Carey, Whelton, & Committee, 2018).…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta‐analysis of randomized controlled trials

Kavyani,

Musazadeh,

Safaei

et al. 2023

Phytotherapy Research

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Clinical studies have suggested that Nigella Sativa (N. sativa) supplementation may effectively reduce blood pressure, but the findings are controversial. Therefore, this study aimed to examine the effects of N. sativa on blood pressure in adults. PubMed, Cochrane Library, Web of Science, Scopus, Embase databases, and Google Scholar were searched till August 2022. To analyze weighted mean differences (WMDs), a random‐effects model was utilized. Nonlinear dose–response analysis and a meta‐regression were conducted. N. sativa supplementation was effective in reducing both systolic (WMD: −3.06 mmHg; 95% CI: −3.89 to −2.22, p < 0.001; I2 = 84.7%, p < 0.001) and diastolic blood pressure (WMD = −2.69 mmHg; 95% CI: −3.72, −1.66, p < 0.001; I2 = 97.3%, p < 0.001). The current meta‐analysis suggests that N. sativa supplementation can improve blood pressure and claims that N. sativa could be used as an effective approach to blood pressure management.

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Management of arterial hypertension: Challenges and opportunities

Cited by 11 publications

References 38 publications

Hipertensão Arterial Sistêmica: Abordagem Clínico-Epidemiológica

Hipertensão Arterial Sistêmica: Abordagem Clínico-Epidemiológica

The role of insulin resistance and oxidative stress in the mechanisms of arterial hypertension development

Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta‐analysis of randomized controlled trials

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