Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial

Szefler, Stanley J.; Mitchell, Herman; Sorkness, Christine A.; Gergen, Peter J.; O’Connor, George T.; Morgan, Wayne J.; Kattan, Meyer; Pongracic, Jacqueline A.; Teach, Stephen J.; Bloomberg, Gordon R.; Eggleston, Peyton A.; Gruchalla, Rebecca S.; Kercsmar, Carolyn M.; Liu, Andrew H.; Wildfire, Jeremy; Curry, Matthew D.; Busse, William W.

doi:10.1016/s0140-6736(08)61448-8

Cited by 410 publications

(449 citation statements)

References 38 publications

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“…Monitoring FeNO in addition to lung function and asthma symptoms has been investigated in pediatric and adult trials, with variable results (60)(61)(62). Its greatest utility appears to be in monitoring ICS compliance in difficult-to-control asthma (63).…”

Section: Measuring Effects and Outcomesmentioning

confidence: 99%

Inhaled Corticosteroids in Lung Diseases

Raissy¹,

Kelly²,

Harkins

et al. 2013

Am J Respir Crit Care Med

112

101

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Section: Measuring Effects and Outcomesmentioning

confidence: 99%

Inhaled Corticosteroids in Lung Diseases

Raissy¹,

Kelly²,

Harkins

et al. 2013

Am J Respir Crit Care Med

112

101

View full text Add to dashboard Cite

“…1,2 Other outcomes included exacerbations, defined as a need for systemic glucocorticoids, hospitalization, or both, in accordance with a recent report by the American Thoracic Society and European Respiratory Society 15 ; the dose of inhaled glucocorticoids needed to maintain asthma control; spirometric measurements; the score on the Childhood Asthma Control Test (C-ACT) 16 ; and the score on the Asthma Control Test (ACT). 17 Scores on the C-ACT and ACT range from 0 to 27 and 5 to 25, respectively, with scores of 20 or more indicating asthma control.…”

Section: Outcome Measuresmentioning

confidence: 99%

“…2 Nonetheless, achieving disease control remains difficult, necessitating a need for additional treatment.…”

mentioning

confidence: 99%

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

Busse¹,

Morgan²,

Gergen³

et al. 2012

Survey of Anesthesiology

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“…2 A number of guidelines have been published (eg, the National Asthma Education and Prevention Program Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma, also known as EPR-3 3 ), and following guideline treatment recommendations improves clinical outcomes. [4][5][6] However, health care providers do not routinely follow asthma guideline recommendations, 7,8 resulting in substandard care and poor health outcomes. [9][10][11][12][13][14] One of the shortcomings of asthma guidelines is the limited extent to which health care providers are provided with tools to follow the recommended care.…”

mentioning

confidence: 99%

Interventions to Modify Health Care Provider Adherence to Asthma Guidelines: A Systematic Review

Butz²,

et al. 2013

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BACKGROUND AND OBJECTIVE: Health care provider adherence to asthma guidelines is poor. The objective of this study was to assess the effect of interventions to improve health care providers' adherence to asthma guidelines on health care process and clinical outcomes. RESULTS: Sixty-eight eligible studies were classified by intervention: decision support, organizational change, feedback and audit, clinical pharmacy support, education only, quality improvement/pay-forperformance, multicomponent, and information only. Half were randomized trials (n = 35). There was moderate evidence for increased prescriptions of controller medications for decision support, feedback and audit, and clinical pharmacy support and low-grade evidence for organizational change and multicomponent interventions. Moderate evidence supports the use of decision support and clinical pharmacy interventions to increase provision of patient self-education/asthma action plans. Moderate evidence supports use of decision support tools to reduce emergency department visits, and low-grade evidence suggests there is no benefit for this outcome with organizational change, education only, and quality improvement/pay-for-performance. METHODS:CONCLUSIONS: Decision support tools, feedback and audit, and clinical pharmacy support were most likely to improve provider adherence to asthma guidelines, as measured through health care process outcomes. There is a need to evaluate health care provider-targeted interventions with standardized outcomes. Pediatrics 2013;132:517-534

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Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial

Abstract: Background-Preliminary evidence is equivocal regarding the role of exhaled nitric oxide in clinical asthma management. This study evaluates the usefulness of eNO as an adjunct to asthma guidelines-based clinical care among inner-city adolescents and young adults.

Cited by 410 publications

References 38 publications

Inhaled Corticosteroids in Lung Diseases

Inhaled Corticosteroids in Lung Diseases

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

Interventions to Modify Health Care Provider Adherence to Asthma Guidelines: A Systematic Review

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