“…Combination therapy may be required ( Figure 14). In patients with HFrEF, beta-blockers, digitalis (digoxin or digitoxin), or their combination should be used, 218,533 as diltiazem and verapamil can have negative inotropic effects in patients with LVEF ,40%. 222,534,535 In critically ill patients and those with severely impaired LV systolic function, intravenous amiodarone can be used where excess heart rate is leading to haemodynamic instability.…”