Pediatric neurology has emerged as an important and flourishing super specialty of pediatrics. Burden of neurological disorders in childhood age group is enormous. About a quarter of chronic childhood problems are neurological in origin. Indian subcontinent faces a great burden of neuro-developmental disorders due to dual challenge of genetic and acquired disease burden posed by nutritional, infectious, toxic, and trau-matic insults. With a pediatric population that constitutes nearly 40% of 1200 million people in India, prev-alence of neurological disorder in community is estimated as 27.5 per 1000 population in age group 6 months- 2 years. Pursuit for healthy offspring has been mentioned as one of the feats of human life. Not only being childless has been a criticism since ancient times but having a child with congenital or develop-mental deformities is also a curse. Ayurveda focuses on preventive measures for healthy progeny. Pan-chakarma helps in improving the quality of progeny. It not only improves the quality of life of child suf-fering from neurodevelopment disorders, but also relieves the physical, mental, and social stress of the cus-todian. This paper aims at highlighting the vast scope of therapeutic efficacies of Panchakarma in pediat-ric neurology.