2018
DOI: 10.3389/fimmu.2018.02708
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Management of Autoimmune Encephalitis: An Observational Monocentric Study of 38 Patients

Abstract: Over the last years the clinical picture of autoimmune encephalitis has gained importance in neurology. The broad field of symptoms and syndromes poses a great challenge in diagnosis for clinicians. Early diagnosis and the initiation of the appropriate treatment is the most relevant step in the management of the patients. Over the last years advances in neuroimmunology have elucidated pathophysiological basis and improved treatment concepts. In this monocentric study we compare demographics, diagnostics, treat… Show more

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Cited by 26 publications
(19 citation statements)
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“…Obviously, follow-up remains necessary to exclude a tumor occurrence. Due to the presence of antibodies with intracellular targets, methylprednisolone seemed the best first-line treatment option(8). We were at this moment nevertheless concerned about a potential worsening of infectious symptoms due to corticosteroids, and we initially started intravenous immunoglobulins.…”
mentioning
confidence: 99%
“…Obviously, follow-up remains necessary to exclude a tumor occurrence. Due to the presence of antibodies with intracellular targets, methylprednisolone seemed the best first-line treatment option(8). We were at this moment nevertheless concerned about a potential worsening of infectious symptoms due to corticosteroids, and we initially started intravenous immunoglobulins.…”
mentioning
confidence: 99%
“…With our patient’s cognitive testing results, the clinical IgLON5 syndrome’s spectrum is expanded to include figural memory impairment. Very few patients with IgLON5 antibody-positive encephalitis and cognitive dysfunction have been reported in the literature so far ( 1 , 2 , 8 11 ). This could be due to both the lack of neuropsychological testing and IgLON5 disease’s broad clinical spectrum—often presenting with predominant sleep dysfunction and motor impairment ( 9 ).…”
Section: Discussionmentioning
confidence: 99%
“…This could be due to both the lack of neuropsychological testing and IgLON5 disease’s broad clinical spectrum—often presenting with predominant sleep dysfunction and motor impairment ( 9 ). So far, the cognitive spectrum of IgLON5 disease covers deficits in attention, information-processing speed, disinhibition and executive dysfunction, as well as impaired verbal memory performance ( 1 , 2 , 8 11 ), often progressing from mild cognitive impairment to dementia ( 10 , 11 ). The pathophysiological mechanism of figural memory dysfunction in IgLON5 disease remains unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Elevated levels of CSF CD138 indicate CD138 + plasma cell entry into the parenchyma, and the activation of neuroinflammation in the brain. Martinez-Hernandez et al (2011) also reported that CD138 + plasma cells were often detected in perivascular, interstitial, and Virchow-Robin spaces in NMDAR-associated encephalitis lesions (Martinez-Hernandez et al, 2011; Macher et al, 2018). We speculate that damage to the endothelial glycocalyx after inflammation may lead to activated B cells crossing the BBB via leaky regions.…”
Section: Discussionmentioning
confidence: 97%