Management of Barrett esophagus: a practical guide for clinicians based on the BADCAT and BoB CAT recommendations

Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury

“…H ydrogen sulfide (H 2 S) is a crucial gaseous mediator of the regulation of vascular tone, blood flow, angiogenesis/granulation tissue (by angiogenic growth factors), inflammation, redox balance which is sufficient for healing gastrointestinal (GI) mucosa [1,2]. More specifically, H 2 S, which easily diffuses through cell membranes, can lead to increased blood flow, mucus secretion, improvement of trophic processes, provision of cytoprotection, decrease leucocyte adhesion and facilitation of cellregeneration in GI organs [3,4]. Thus, the functional effects of H 2 S is very important in the prevention and treatment of GI mucosal damage.…”

“…The non-erosive diseases of upper part of the gastrointestinal (GI) tract, as esophagitis, Barrett esophagus or gastritis are the prevalent among acid-related diseases. Last data recognized them as disorders, which characterized by low-grade inflammation, which is, according to the WHO, is the background for several pre-malignant conditions, e.g., Barrett esophagus metaplasia for esophageal adenocarcinoma, ones of highest aggressive tumor with very poor prognosis [4]. Latest evidence-based data has shown the use of non-steroid anti-inflammatory drugs (NSAID), including aspirin, is implicate to cancer chemoprevention, including suppression of several pro-inflammatory pathways, as cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), β-catenin nuclear translocation and mitogen-activated protein kinase signaling [5,6].…”