This study aims to explore the treatment effect of different ovulation induction programs on patients with ovulatory infertility, for which 82 infertility patients who visiting our hospital from January 2013 to December 2018 were elected for sampling. All patients were divided into an experimental group and a control group according to the random number table method, with 41 cases in each group. The experimental group was treated with letrozole and clomiphene therapy; the control group was only treated with letrozole. The clinical comprehensive efficacy, ovulation rate and pregnancy rate of the two groups were compared in the study. The result shows that after the treatment, the ovulation rate and pregnancy rate of the two groups were significantly higher than those before treatment, and the experimental group was significantly better than the control group (p<0.05). It is found that, for patients with ovulatory infertility who were treated with both letrozole and clomiphene therapy, their endometrial thickness on Human chorionic gonadotropin injection days is more suitable for implantation of germ cell, and their pregnancy rate, serum hormone levels, follicular development, ovulation and endometrial growth were superior to than those who only treated with letrozole. Moreover, this method can also take advantage of the respective advantages of Chinese and Western medicine, make the best of each other's strengths, treat both the symptoms and the root causes, and improve the clinical pregnancy rate. In the future research, it is necessary to combine the physiology, pathology and other multidisciplinary discussions to propose a more effective treatment plan.