2017
DOI: 10.1159/000481438
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Management of Biochemical Recurrence after Primary Curative Treatment for Prostate Cancer: A Review

Abstract: How to manage patients with prostate cancer (PCa) with biochemical recurrence (BCR) following primary curative treatment is a controversial issue. Importantly, this prostate-specific antigen (PSA)-only recurrence is a surrogate neither of PCa-specific survival nor of overall survival. Physicians are therefore challenged with preventing or delaying the onset of clinical progression in those deemed at risk, while avoiding over-treating patients whose disease may never progress beyond PSA-only recurrence. Adjuvan… Show more

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Cited by 176 publications
(163 citation statements)
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“…Overall rates of PSMs vary from 11 to 38% in open series and from 12 to 32.8% in robot-assisted series [7,14]; moreover, they are not influenced by the 2 approaches [15,16]. Literature patterns of PSMs were confirmed by our study.…”
Section: Discussionsupporting
confidence: 76%
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“…Overall rates of PSMs vary from 11 to 38% in open series and from 12 to 32.8% in robot-assisted series [7,14]; moreover, they are not influenced by the 2 approaches [15,16]. Literature patterns of PSMs were confirmed by our study.…”
Section: Discussionsupporting
confidence: 76%
“…Thus, beyond surgical factors, tumor biology has a pivotal independent role on surgical margins status. Independent clinical predictors of PSMs include BMI, PSA, TPV, PSA density, biopsy tumor grade, and surgical factors [6,7,14].…”
Section: Discussionmentioning
confidence: 99%
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“…Patients with biochemical evidence of recurrence, which can occur in up to one‐third of men treated primarily with surgery or radiation therapy, are problematic, and treatment strategies in such patients can include androgen deprivation therapy (although this is associated with substantial side effects), radiotherapy, brachytherapy, proton therapy, and HIFU . All salvage treatments are more toxic to the patient than the primary treatment .…”
Section: High‐intensity Focused Us In the Treatment Of Recurrencementioning
confidence: 99%