Management of blood supplies during an influenza pandemic

Kamp, Christel; Heiden, M.; Henseler, Olaf; Seitz, Rainer

doi:10.1111/j.1537-2995.2009.02498.x

Cited by 49 publications

(40 citation statements)

References 31 publications

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“…Animals were considered suitable for experiments if (1) systemic parameters were within the normal range, namely: heart rate (HR) greater than 340 bpm, mean arterial pressure (MAP) greater than 80 mmHg, systemic Hct greater than 45% and arterial oxygen partial pressure (PaO 2 ) greater than 50 mmHg; and (2) microscopic examination of the tissue in the chamber observed under 20X magnification did not reveal signs of edema, bleeding or unusual neovascularization. Hamsters, fossorial animals that have adapted to an underground environment, have lower arterial PO 2 than other rodents.…”

Section: Methodsmentioning

confidence: 99%

“…However, the supply of blood is particularly vulnerable to pandemics (2, 3) and blood transfusion-related adverse events, both short- and long-term is among the costliest contributor to health care expenditures (4). In addition, the availability of blood is limited in emergency situations such as in war zones or after natural disasters (5).…”

Section: Introductionmentioning

confidence: 99%

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Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

Ortiz

Barros

et al. 2014

The American Journal of Emergency Medicine

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The development of an alternative to blood transfusion to treat severe hemorrhage remains a challenge, especially in far forward scenarios when blood is not available. Hemoglobin (Hb) based oxygen (O2) carriers (HBOCs) were developed to address this need. Hemopure® (HBOC-201, bovine Hb glutamer-250, OPK Biotech, Cambridge, MA, USA), one such HBOC, has been approved for clinical use in South Africa and Russia. At the time of its approval, however, few studies aimed to understand Hemopure’s function, administration, and adverse effects compared to blood. We used intravital microscopy to study the microcirculation hemodynamics (arteriolar and venular diameters and blood flow and functional capillary density (FCD)) and oxygenation implications of Hemopure® administration at different Hb concentrations —4, 8, and 12 gHb/dL— compared to fresh blood transfusion during resuscitation from hemorrhagic shock. Experiments were performed in unanesthetized hamsters instrumented with a skinfold window chamber, subjected to hemorrhage (50% of the blood volume, BV), followed by 1 hour hypovolemic shock and fluid resuscitation (50% of the shed volume). Our results show that fluid resuscitation with Hemopure® or blood restored systemic and microvascular parameters. Microcirculation O2 delivery was directly correlated with Hemopure® concentration, though increased vasoconstriction was as well. FCD reflected the balance between enhanced O2 transport and reduced blood flow: 12 gHb/dL of Hemopure® and blood decreased FCD compared to the lower concentrations of Hemopure® (p<0.05). The balance between O2 transport and tissue perfusion can provide superior resuscitation from hemorrhagic shock compared to blood transfusion by using a low Hb concentration of HBOCs relative to blood.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

Ortiz

Barros

et al. 2014

The American Journal of Emergency Medicine

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“…Dort lag im Jahr 2006 der Median bei 36 EK pro 1000 Einwohner (Quartilsabstand: 48-29), in Deutschland bei 55 [5]. Detaillierte Untersuchungen zur Versorgung mit EK haben gezeigt, dass im Jahresverlauf die Bereitstellung von EK um bis zu 20% schwanken kann [12]. Offenbar sind die Einrichtungen der Krankenversorgung in der Lage, durch Priorisierung und entsprechende Planung von Operationen vorübergehende Versorgungsengpässe zu überwinden.…”

Section: Tab 3 Produkte Aus Fremdblut (Vollblut-und Apheresespenden)unclassified

Bericht zur Meldung nach § 21 TFG für die Jahre 2008 und 2009

Henseler

Heiden

Haschberger

et al. 2010

Bundesgesundheitsbl.

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This report contains the data collected in 2008 and 2009, pursuant to Section 21 of the German Transfusion Act (Transfusionsgesetz), as well as an overview of the supply situation during the last 10 years. In 2009, blood donation services reported a total of 7.5 million donations--the largest amount since 2000. At the same time, more than 4.7 million red blood cell concentrates and more than 500,000 platelet concentrates were available. The number of therapeutic single plasma units decreased to 1.1 million units in 2009. The loss rate for red blood cell concentrates is still between 3% and 4% for the users, while for the manufacturers, it has decreased slightly to 1.4%. The loss rate, for platelet concentrates, on the other hand, increased in 2009, and--what is noteworthy--especially for manufacturers of pooled platelet concentrates. The loss rate for apheresis platelet concentrates accounted for 5.2% compared to 17.5% for pooled platelet concentrates. As far as the users were concerned, loss rates for platelet concentrates largely remained unchanged with rates between 5% and 6%. Based on the data collected, the supply of blood components for transfusion can be regarded as assured. Nearly 2.9 million liters of plasma for fractionation were collected in Germany in 2009. According to reports from the pharmaceutical industry, of these, 2.6 million liters remained on the German market, of which only 56% were fractionated in this country; no statement can be made on the use of the remaining amount. Many plasma derivatives are not manufactured in Germany, despite the large amount of plasma collected. The supply with these products, however, is assured by imports. Overall, 16,409 autologous and 9,435 allogeneic hematopoietic stem cell preparations were manufactured in 2009, of which 3,382 allogeneic preparations were exported. A total of 3,181 autologous and 2,374 allogeneic preparations were transplanted; 187 of these products from imports. The large number of exported stem cells and the small number of imported stem cells suggest that no serious shortages are to be expected for the supply with these products.

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“…Crawford et al (5) evaluated weekly donation rates from 1995 to 2005 among three Red Cross donor regions in the USA and found a great deal of variation, particularly among younger donors. However, most of the studies correlate donation variation with natural catastrophes, such as the earthquake in China (6) , terrorist attacks, such as September Eleven (7) , or viral epidemics, like influenza outbreaks (8) .…”

Section: Introductionmentioning

confidence: 99%

Temporal distribution of blood donations in three Brazilian blood centers and its repercussion on the blood supply

Oliveira¹,

Almeida‐Neto²,

Liu³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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BackgroundSeasonal distribution of blood donation hinders efforts to provide a safe and adequate blood supply leading to chronic and persistent shortages. This study examined whether holidays, geographical area and donation type (community versus replacement) has any impact on the fluctuation of donations. MethodsThe numbers of blood donations from 2007 through 2010 in three Brazilian Retrovirus Epidemiological Donor Study II (REDS-II) participating centers were analyzed according to the week of donation. The weeks were classified as holiday or non-holiday. To compare donations performed during holiday versus non-holiday weeks, tabulations and descriptive statistics for weekly donations by blood center were examined and time series analysis was conducted. ResultsThe average weekly number of donations varied according to the blood center and type of week. The average number of donations decreased significantly during Carnival and Christmas and increased during the Brazilian National Donor Week. The fluctuation was more pronounced in Recife and Belo Horizonte when compared to São Paulo and higher among community donors. ConclusionNational bank holidays affect the blood supply by reducing available blood donations. Blood banks should take into account these oscillations in order to plan local campaigns, aiming at maintaining the blood supply at acceptable levels.

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Management of blood supplies during an influenza pandemic

Cited by 49 publications

References 31 publications

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

Resuscitation from hemorrhagic shock using polymerized hemoglobin compared to blood

Bericht zur Meldung nach § 21 TFG für die Jahre 2008 und 2009

Temporal distribution of blood donations in three Brazilian blood centers and its repercussion on the blood supply

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