Narrow brown leaf spot disease of rice caused by fungus Cercospora oryzae Miyake emerged as potential threat to rice crop in previous few years worldwide and can cause more than 40% yield loss. The disease symptoms were noted on various commercially important rice varieties in the rice growing districts of Punjab province of Pakistan. Hence, the studies were planned to assess the effects of Propiconazole fungicide application timings and different rice varieties on the severity of narrow brown leaf spot (NBLS) disease of rice to develop an accurate management strategy for the disease. The Propiconazole fungicide was tested at three various growth phases (early booting, late booting, and soft dough) of four rice varieties against the percent severity of the NBLS disease The experiments were designed under strip-plot (crisscross) design with four replications at research area of Plant Pathology Department, University of Agriculture Faisalabad. Analysis of variance has demonstrated that the main and interactive effects of fungicide applications and rice varieties were found significant. The main effects of years were found non-significant but their interactions with fungicide application timings and rice varieties were significant. Fungicide applications at soft dough and late booting phases of rice variety B-515 were found least effective to reduce the disease severity, respectively. Fungicide application at early booting of rice variety PK-1121 was found most effective by reducing the maximum percent diseases severity (47.25%) compared to control. It is concluded that, to minimize hazardous effects of chemicals on the environment by practicing multiple sprays at inappropriate growth phases of rice crop, fungicides must be applied during the early and late booting phases of rice varieties on mildly resistance, susceptible and highly susceptible rice varieties to reduce NBLS disease severity and to enhance the rice production and quality