Management of Cancer Pain

Money, Sarah; Garber, Boris

doi:10.1007/s40138-018-0170-9

Cited by 27 publications

(19 citation statements)

References 24 publications

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“…Current treatment of cancer pain relies mostly on opioids like morphine, fentanyl, buprenorphine, tramadol and others (Money and Garber 2018). Many ways of administrations are available for the opioids including oral, transdermal, transmucosal or via enteral tubes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020

Matalińska

Lipiński

Kotlarz

et al. 2020

Int J Pept Res Ther

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In the present contribution we report design, synthesis and evaluation of receptor affinity, analgesic activity and cytotoxicity of a hybrid peptide, AWL3020. The peptide includes two pharmacophores, one of δ-opioid receptor (δOR) agonists and one of neurokinin-1 receptor (NK1R) antagonists. The design was motivated by the desire to obtain a compound with strong analgesic action and potential additional antiproliferative action. The compound displays high δOR affinity (IC 50 = 29.5 nM). On the other hand, it has only poor affinity for the NK1R (IC 50 = 70.28 μM). The substance shows good analgesic action which is however weaker than that of morphine. Regarding the effect on proliferation, the compound exhibits no pro-proliferative action in the assayed range. In higher concentrations, it has also cytotoxic activity. This effect is however not selective. The strongest effect of AWL3020 was found for melanoma MeW164 cell line (EC 50 = 46.27 μM in reduction of cell numbers after a few days of incubation; EC 50 = 37.78 μM in MTT assay).

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Section: Introductionmentioning

confidence: 99%

Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020

Matalińska

Lipiński

Kotlarz

et al. 2020

Int J Pept Res Ther

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“…A simplified version of this classification system includes the presence or absence of the risk factors mentioned above, the presence of more risk factors (presence of nociceptive pain, neuropathic pain, or presence of breakthrough pain; as well as psychologic distress, addictive behavior, or cognitive dysfunction) indicating a poorer prognosis. 1 To evaluate neuropathic pain, a douleur neuropathique (DN4) questionnaire can be used, which consists of a series of yes/no questions given by doctors regarding the characteristics of pain such as burning, tingling, numbness, or temperature sensations that change, as well as objective findings about clinical examination, such as decreased sensation of needle pricking and light touch and allodynia. Assessments are from 0 to 10, with scores >4 likely to indicate neuropathic pain.…”

Section: Biomedical Classifying and Treating Cancer-related Painmentioning

confidence: 99%

“…The prevalence of pain in cancer reaches 50% in patients undergoing active treatment for malignancy, and up to 90% in patients with advanced cancers. 1 Cancer-related pain can be caused by primary cancer itself, metastases, interventions to treat cancer (surgery, chemotherapy, and radiotherapy). However, the main cause of the pain cannot always be identified.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of pain is also related to the type of cancer, and age, with younger patients experiencing more pain. 1,2 Almost all cancer-related pain is pain with moderate-tosevere intensity. Thus, cancer-related pain management often involves administration of opioid analgesics.…”

Section: Introductionmentioning

confidence: 99%

“…Often patients with cancer have mixed kinds of pain that require combination therapy. 1 In nociceptive pain, after the nociceptors are stimulated, impulses are transmitted first by the nerve fibers (Ad, thin myelinated) and then by the slower nerve fibers (C, unmyelinated). These fibers terminate in the dorsal root of the spinal cord or trigeminal ganglion, which then interact with neurons in the central nervous system (CNS) in the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

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The Roles of Battlefield Acupuncture and Electroacupuncture in a Patient with Cancer-Related Pain

Irman

Helianthi

2020

Medical Acupuncture

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Background: Pain is one of the most-frightening complications of cancer and disrupts quality of life. Cancerrelated pain can be caused by primary cancer itself, metastases that occur, and interventions to treat cancer. Almost all cancer-related pain is pain with moderate-to-severe intensity. Thus, cancer-related pain management often involves administration of opioid analgesics. However, administration of opioid analgesics can cause side-effects that cause new problems for these patients. Several studies have shown that acupuncture can reduce cancer-related pain and data show that acupuncture therapy is safe and can provide clinically meaningful improvements when used in conjunction with standard therapy. Case: A 72-year-old female patient had pain throughout her body since 1 month prior to before being admitted to the hospital. She was unable to sleep at night often cried because she was unable to stand the pain. This was reduced by morphine 3 • /day. Because of the drug's side-effects, she slept more often during the day, could not sleep at night, and was constipated. She also had breakthrough pain, on an average of 2-3 • /day. She had a history of malignancy in the pleura, liver, lungs, and cervix. There was an increase in some tumor markers. Her baseline numeric rating scale (NRS) assessment was 4 with an oral morphine slow-release tablet 3 • 15 mg/day. Acupuncture therapy was performed at Battlefield Acupuncture points of the right ear and body acupuncture points (LI 4, LI 11, ST 36, SP 6, and LR 3) was treated with 3-Hz continuous-wave electroacupuncture for 30 minutes at each session. During this therapy, there were reductions in pain (baseline NRS 4 became 2), need for morphine, morphine side-effects, and frequency of breakthrough pain. There were no significant side-effects due to acupuncture. Conclusions: Acupuncture is an effective and safe therapeutic option for reducing cancer pain with minimal side-effects. Acupuncture can enable a reduced need for narcotic analgesics.

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The evolution of perioperative pain management in otolaryngology—head and neck surgery

Achim

Mularczyk

Abud

2022

Opioid Use, Overuse, and Abuse in Otolaryngology

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Management of Cancer Pain

Cited by 27 publications

References 24 publications

Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020

Evaluation of Receptor Affinity, Analgesic Activity and Cytotoxicity of a Hybrid Peptide, AWL3020

The Roles of Battlefield Acupuncture and Electroacupuncture in a Patient with Cancer-Related Pain

The evolution of perioperative pain management in otolaryngology—head and neck surgery

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