Management of Cardiovascular Disease Risk in Rheumatoid Arthritis

Dessein, Patrick H

doi:10.3390/jcm11123487

Cited by 6 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by inflammation and bone damage (Felson et al, 2022; Wiegmann et al, 2022). Its clinical manifestations are poor joint function, swelling, and pain, and later progression can cause joint deformity and dysfunction (Dessein & Gonzalez‐Gay, 2022; Dijkshoorn et al, 2022). According to clinical epidemiological statistics, the average prevalence of RA globally is 0.5%–1.0%.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Jinteng Qingbi granules in the treatment of rheumatoid arthritis using metabolomics analysis

Tang,

Wang,

Zhou

et al. 2024

Biomedical Chromatography

View full text Add to dashboard Cite

This study investigated the differential metabolites after rheumatoid arthritis (RA) rats were treated with Jinteng Qingbi granules. Collagen‐induced arthritis rats were divided into three groups, namely normal group, model group, and Jinteng Qingbi granules group. Serum compounds were identified, annotated, and classified using metabolomics to explain the physicochemical properties and biological functions. The metabolites were screened using univariate and multivariate statistical analyses. There were differences in serum metabolites between RA and normal rats; Jinteng Qingbi granules improved RA and recovered the metabolite levels to normal. Compared to the normal group, 51 differential ions were screened, and 108 ions were changed in the Jinteng Qingbi granules group compared to the RA model. Eight metabolites were upregulated in the RA model group compared to the normal group, whereas 10 metabolites were downregulated. Treatment with Jinteng Qingbi granules increased the levels of 12 metabolites such as cinnamate and decreased the levels of 16 metabolites such as allamandin in the RA model. Differential ion enrichment was mainly related to the histidine metabolic pathway in amino acid metabolism. Jinteng Qingbi granules resulted in improvements in the RA model, which were mainly associated with lipids and lipid‐like molecules, organic acids, and derivatives, providing a new possibility and basis for screening biomarkers for the diagnosis and treatment of RA.

show abstract