Management of carotid body tumors

Mey, Andel G. L. van der; Jansen, Jeroen C.; Baalen, Jary M. van

doi:10.1016/s0030-6665(05)70354-6

Cited by 87 publications

(71 citation statements)

References 39 publications

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“…It may be prudent to evaluate all patients with suspected pheochromocytomas or paragangliomas for elevated catecholamine production. This recommendation has also been suggested by van der Mey et al for the management of carotid body tumors (16). Compared to urinary dopamine, plasma methoxytyramine (an Omethylated metabolite of dopamine) has been reported to be a better marker for tumors that secrete predominantly dopamine (2).…”

Section: Dopamine-secreting Paragangliomasmentioning

confidence: 89%

Dopamine-secreting Carotid Body Paragangliomas-Biochemical Control with Radiotherapy

Soh

Kek

2012

Intern. Med.

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Head and neck paragangliomas that are exclusively or predominantly dopamine-secreting are rare. Surgery and/or radiotherapy are modalities for locoregional tumoral control. Little is known about the efficacy of radiotherapy for biochemical control in such tumors. We report a 62-year-old Chinese man with bilateral carotid body tumors which were exclusively dopamine secreting. The left-sided tumor invaded the skull base and encased the left carotid artery. Surgery was not performed due to high risk of morbidity and mortality. The patient received external beam radiotherapy to bilateral neck regions. Progressive decline and eventual normalization of urinary dopamine excretion was seen together with a slight reduction in tumor size. This is the first report demonstrating the efficacy of radiotherapy for both biochemical and locoregional control of functioning carotid body paragangliomas.

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Section: Dopamine-secreting Paragangliomasmentioning

confidence: 89%

Dopamine-secreting Carotid Body Paragangliomas-Biochemical Control with Radiotherapy

Soh

Kek

2012

Intern. Med.

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“…Also sounds and murmurs can be heard through auscultation. Tumor's progressive growth may cause symptoms like dysphagia, odinophagia and hoarseness because of the anatomical neighbourhood of the 10 and 12 cranial nerves and the carotid vessels [7].…”

Section: Discussionmentioning

confidence: 99%

Carotid Body Tumors and Our Surgical Approaches

Şanlı

Öz

Ayduran

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Glomus tumors known as paragangliomas are neoplasms arising from the neural crest. They are named according to the place they originate from. Tumors originating from the carotid body at the carotid bifurcation are called Carotid Body Tumors (CBT). Surgical intervention is planned according to the Shamblin classification. 17 patients were operated after being diagnosed with CBT in our clinic between February 2007 and June 2010. 12 (70.5%) of the patients were male, and 5 (29.4%) of the patients were female. The average age was 42 (ages ranging between 32 and 47). Nine of the patients were diagnosed and treated with Shamblin type I tumor, seven of the patients with type II and one patient with type III. Only one patient had bilateral carotid tumor. In all patients with Shamblin type I and II, blunt dissection of the tumor was conducted smoothly by means of thermal cautery in the subadventitial plane. The patient with Shamblin type III had tumor invasion in the carotid artery and adjacent tissues were in an adherent state. Therefore mass resection was carried out by resecting 2 cm of the distal portion of the common carotid artery and 3 cm of the proximal portion of the internal carotid artery. 6 mm of synthetic polytetrafluoroethylene graft was interpositioned between the common carotid artery and the internal carotid artery. External carotid artery was anastomosed to this graft in an end-to-end fashion. The patient developed vocal cord paralysis postoperatively on the lesion side. The patient who underwent bilateral tumor excision developed Baroreflex Failure Syndrome. In the two patients thrombus developed in the internal carotid artery in the early postoperative period. These patients underwent thrombectomy and developed hemiplegia on the lesion side. One of them died on the seventh post-operative day while in follow-up in the intensive care unit. Surgical resection is the recommended treatment for carotid body tumors. Shamblin I and II type tumors' dimensions and pathological characteristics allow dissection. However Shamblin III tumors may require carotid artery resection and reconstruction due to tissue invasion. The possibility of post-operative cranial nerve paralysis and arterial thrombosis should be taken into account.

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“…As the tumour grows, dysphagia, odynophagia, dysphonia, and symptoms due to compression of cranial nerves 9 to 12 may be seen [9][10][11] . The most commonly involved cranial nerve is the vagus, up to one third of all cases will show cranial nerve palsies.…”

Section: Discussionmentioning

confidence: 99%