Management of Cepacia syndrome in an immunocompetent non-cystic fibrosis adult patient

Pneumatocele after lung transplantation

“…Staphylococcus aureus infections often cause necrotizing pneumonia, which is thought to result in necrosis of the bronchi and check valve mechanism leading to pneumatocele [1]. In addition to Staphylococcus aureus, Burkholderia cepacia was also detected in this case, which may have caused the fatal cepacia syndrome complicated by necrotizing pneumonia, rapid respiratory decline, and bacteremia [2]. This case had a such severe respiratory failure that oxygenation could not be maintained even with mechanical ventilation and VV-ECMO.…”

A Case of Burkholderia cepacia Sepsis in a postpartum patient with colonic perforation due to Ogilvie's syndrome: Case from a tertiary care hospital in Bangladesh

“…Burkholderia cepacia is one of the species in Burkholderia cepacia complex. Being ubiquitous in nature, and unbelievable ability to form symbiotic relationship with amoeba and fungi has allowed it to thrive in a diverse range of environment 1,2,5,6 . It has been found to survive in diverse aqueous medicated solution such as intravenous fluid, irrigation fluid, antiseptic solutions, mouthwash,inhaler solutions, ultrasound gel and even respiratory therapy equipments.…”

“…3,4 Orthodoxly it is found in patients in cystic fibrosis and patients with chronic airway disease. It has been shown to infect hospitalized patients more commonly who are on haemodialysis, have recent abdominal surgery, underwent bronchoscopic procedure, or having presence of central catheters.Being highly resistant to traditional multiple antimicrobials, the treatment is also very challenging and longer duration treatment is also required 2,3,4,5,6 . On the other hand,acute colonic pseudo-obstruction or, Ogilvie's syndrome is also a relatively uncommon phenomenon, characterized by colonic obstruction without an identifiable mechanical cause.Though associated with wide medical and surgical conditions, most commonly it has been reported after caesarean section 7 .Though pathogenesis is unknown, and assumed to be multifactorial, butan unknown disturbance to autonomic innervation of distal colon, more precisely parasympathetic S2-S4, is being postulated 7,8 .…”

“…Burkholderia cepacia complex, discovered by Walter Burkholder in 1949, refers to a group of catalase negative, non-lactose fermenting, aerobic gram negative rods 1,2, . In humans it is an opportunistic pathogen mainly seen in patients with cystic fibrosis or, immunocompromised states such as chronic granulomatous disease or, inpatients post lung transplantation [1][2][3][4][5][6] . Being resistant to multiple antimicrobials it is very notorious to treat.…”