Management of Cervical Precancers: A Global Perspective

Echelman, Daniel J.; Feldman, Sarah

doi:10.1016/j.hoc.2011.11.005

Cited by 35 publications

(34 citation statements)

References 57 publications

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“…Women in developing nations are at a 35% greater lifetime risk of developing cervical cancer than women in high-income countries. Although cervical cancer is most common in women older than 50 years, in developing nations, it is becoming increasing prevalent among women during their reproductive age 15-49 years [6].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Cervical Cancer and Associated Risk Factors among Women Attending Cervical Cancer Screening and Diagnosis Center at Yirgalem General Hospital, Southern Ethiopia

Hailemariam¹,

Yohannes²,

Aschenaki³

et al. 2017

J Cancer Sci Ther

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Introduction: A worldwide estimated annual case of cervical cancer is 493,000 and ends with 273,500 annual deaths. In developing countries, it accounts for about 85% of both its morbidity and mortality. According to the report from World health organization, globally in 2012, cervical cancer incidence was 7.9%, mortality 7.5% and five-year prevalence was 9%. In sub-Saharan Africa the incidence was 25.2%, mortality 23.2% and five-year prevalence was 27.6%. In Ethiopia the incidence was 17.3%, mortality 16.5% and five-year prevalence was 18.2%. Results: from the screened clients, 16.5% had cervical cancer. From the screened and diagnosed clients those with multiple sexual partners had 40 times higher odd of cervical than those with no multiple sexual partners. This study revealed that being Human immune deficiency virus positive (AOR=9.033: 95%: CI 4.537, 17.985), sexually transmitted infection history (AOR=8.364:95% CI: 5.639, 12.405) and early age at initiation of sexual intercourse (AOR=8.968:95%: CI 5.588, 14.393) have statistically significantly associated with cervical cancer in multivariate analysis Conclusion: Of screened clients, 16.5% were with acetone white lesion and the risk factors for cervical cancer were having multiple sexual partners, human immune deficiency virus positive, history of sexually transmitted infection and early age at initiation of sexual intercourse. Early screening on mass campaign and focus from the government and other stake holders by strengthening both cancer prevention and control program and implementation strategies through due attention on the associated risk factors of the study. Methods

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Section: Introductionmentioning

confidence: 99%

“…It is the most common among women of sub-Saharan Africa following breast cancer in northern Africa [6]. In South Africa, cervical cancer is the most common cancer in black women and fourth among white women.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Cervical Cancer and Associated Risk Factors among Women Attending Cervical Cancer Screening and Diagnosis Center at Yirgalem General Hospital, Southern Ethiopia

Hailemariam¹,

Yohannes²,

Aschenaki³

et al. 2017

J Cancer Sci Ther

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“…Infection with human papillomavirus (HPV), particularly high-risk (HR) HPV (e.g. HPV16 or 18), is an important factor in SCC progression [4,5]. Positive HR HPV infection has been reported in all SCC patients with cervical cancer and most patients with precancerous lesions (cervical intraepithelial neoplasia [CIN] II-III) [6].…”

Section: Introductionmentioning

confidence: 99%

Tissue-based metabolomics reveals potential biomarkers for cervical carcinoma and HPV infection

Abudula¹,

Rouzi²,

Xu³

et al. 2019

Bosn J of Basic Med Sci

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Aberrant metabolic regulation has been observed in human cancers, but the corresponding regulation in human papillomavirus (HPV) infection-associated cervical cancer is not well understood. Here, we explored potential biomarkers for the early prediction of cervical carcinoma based on the metabolic profile of uterine cervical tissue specimens that were positive for HPV16 infection. Fifty-two fresh cervical tissues were collected from women confirmed to have cervical squamous cell carcinoma (SCC; n = 21) or cervical intraepithelial neoplasia (CIN) stages II-III (n = 20). Eleven healthy women constituted the controls (negative controls [NCs]). Real-time polymerase chain reaction (PCR) was performed to detect HPV infection in the tissues. High-resolution magic angle spinning nuclear magnetic resonance was utilized for the analysis of the metabolic profile in the tissues. The expression of rate-limiting enzymes involved in key metabolic pathways was detected by reverse-transcription quantitative PCR. An independent immunohistochemical analysis was performed using 123 cases of paraffin-embedded cervical specimens. A profile of 17 small molecular metabolites that showed differential expression in HPV16-positive cervical SCC or CIN II-III compared with HPV-negative NC group was identified. According to the profile, the levels of α-and β-glucose decreased, those of lactate and low-density lipoproteins increased, and the expression of multiple amino acids was altered. Significantly increased transcript and protein levels of glycogen synthase kinase 3 beta (GSK3β) and glutamate decarboxylase 1 (GAD1) and decreased transcript and protein levels of pyruvate kinase muscle isozyme 2 (PKM2) and carnitine palmitoyltransferase 1A (CPT1A) were observed in the patient group (p < 0.05). HPV infection and cervical carcinogenesis drive metabolic modifications that might be associated with the aberrant regulation of enzymes related to metabolic pathways.

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“…Orf virus infection in humans was first reported in 1934 by Newsome and Cross (Newsome et al 1934). Since then, human infections caused by occupational or household exposures have been reported (Moore 1973, Bayindir et al 2011, Echelman and Feldman 2012, Nougairede et al 2013. Human Orf lesions most commonly develop on the hands (Lederman et al 2007, Karakas et al 2013, and these sores may become infected with bacteria, if they are not properly managed.…”

Section: Introductionmentioning

confidence: 99%

Human Infection with Orf Virus from Goats in China, 2012

Zhang

Liu²,

Kong³

et al. 2014

Vector-Borne and Zoonotic Diseases

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Orf virus, which belongs to the Parapoxvirus genus, induces a zoonotic infectious disease characterized by acute, highly vascularized cutaneous pustular lesions in sheep and goats. A number of Orf outbreaks have been reported in sheep and goats in recent years, but no reports have described an Orf virus strain from humans in China. In this study, we diagnosed Orf virus infection in two people, a mother and son, in the Gansu province of China. The human Orf virus was isolated and its phylogenetic characterization was analyzed based on a complete B2L gene. The results are useful for developing prospective programs to control Orf virus infections in both goats and humans

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Management of Cervical Precancers: A Global Perspective

Cited by 35 publications

References 57 publications

Prevalence of Cervical Cancer and Associated Risk Factors among Women Attending Cervical Cancer Screening and Diagnosis Center at Yirgalem General Hospital, Southern Ethiopia

Prevalence of Cervical Cancer and Associated Risk Factors among Women Attending Cervical Cancer Screening and Diagnosis Center at Yirgalem General Hospital, Southern Ethiopia

Tissue-based metabolomics reveals potential biomarkers for cervical carcinoma and HPV infection

Human Infection with Orf Virus from Goats in China, 2012

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